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Increased pulsatility index of the basilar artery is a risk factor for neurological deterioration after stroke: a case control study

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Issue Date
2022-08-15
Publisher
BMC
Citation
Clinical Hypertension, 28(1):27
Keywords
Basilar arteryStrokeTranscranial Doppler sonographyNeurological deterioration
Abstract
Background : Higher pulsatility of the middle cerebral artery (MCA) is known to be associated with stroke progression. We investigated whether pulsatility index (PI) of the basilar artery (BA) can predict neurological deterioration (ND) after acute cerebral infarction.
Methods : A total of 708 consecutive patients with acute ischemic stroke who had undergone transcranial Doppler (TCD) ultrasonography were included. ND was defined as an increase in the National Institutes of Health Stroke Scale scores by two or more points after admission. The patients were categorized into quartiles according to BA PI. Multivariable logistic regression analysis was performed to examine whether BA PI is independently associated with ND.
Results : BA PI was well correlated with the right (n = 474, r2 = 0.573, P < 0.001) by Pearson correlation analysis although MCA PI could not be measured from right MCA (n = 234, 33.05%) and left MCA (n = 252, 35.59%) by TCD owing to insufficient temporal bone window. Multivariable logistic regression analysis including age, sex, cerebral atherosclerosis burden, National Institutes of Health Stroke Scale at admission, and the proportion of patients with current smoking status, hypertension, diabetes mellitus, atrial fibrillation revealed that the higher BA PI (odds ratio, 3.28; confidence interval, 1.07–10.17; P = 0.038) was independently associated with ND.
Conclusions : BA PI, which would be identified regardless of temporal window, could predict ND among acute stroke patients.
ISSN
2056-5909
Language
English
URI
https://doi.org/10.1186/s40885-022-00210-9

https://hdl.handle.net/10371/184486
DOI
https://doi.org/10.1186/s40885-022-00210-9
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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