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Small-molecule modulators of protein-RNA interactions

Cited 1 time in Web of Science Cited 1 time in Scopus
Authors

Byun, Wan Gi; Lim, Donghyun; Park, Seung Bum

Issue Date
2022-06
Publisher
Elsevier BV
Citation
Current Opinion in Chemical Biology, Vol.68, p. 102149
Abstract
Protein-RNA interactions (PRIs) play crucial roles in diverse cellular pathways, from transcription to liquid-liquid phase separation, and its dysregulation is associated with a wide range of human disorders. Therefore, there is great emphasis on discovering small-molecule modulators that target unexplored PRIs by developing robust PRI assays. In particular, targeting PRIs could offer innovative solutions to expand the druggable genome, as only a small portion of protein-coding genes are currently targeted by drugs. This review describes the therapeutic potential of targeting PRIs using small molecules, biochemical and cell-based experimental tools for observing PRIs, and several PRI modulators. We also highlight emerging technologies and the challenges in developing PRI modulators.
ISSN
1367-5931
URI
https://hdl.handle.net/10371/184826
DOI
https://doi.org/10.1016/j.cbpa.2022.102149
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