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Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Won Jung | - |
dc.contributor.author | Lee, Eu Hyun | - |
dc.contributor.author | Kwon, Yong-Jin | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Kim, Kyu Oh | - |
dc.date.accessioned | 2022-10-05T04:11:13Z | - |
dc.date.available | 2022-10-05T04:11:13Z | - |
dc.date.created | 2022-07-13 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | RSC Advances, Vol.12 No.28, pp.18209-18214 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185328 | - |
dc.description.abstract | An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 +/- 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line. | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Targeted drug release system based on pH-responsive PAA-POSS nanoparticles | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d2ra01141g | - |
dc.citation.journaltitle | RSC Advances | - |
dc.identifier.wosid | 000814227700001 | - |
dc.identifier.scopusid | 2-s2.0-85133224110 | - |
dc.citation.endpage | 18214 | - |
dc.citation.number | 28 | - |
dc.citation.startpage | 18209 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Ye, Sang-Kyu | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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