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HLA-A24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B58:01 carriers in a Korean population; a multicenter cross-sectional case-control study
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi-Yeong | - |
dc.contributor.author | Yun, James | - |
dc.contributor.author | Kang, Dong-Yoon | - |
dc.contributor.author | Kim, Tae Hee | - |
dc.contributor.author | Oh, Min-Kyung | - |
dc.contributor.author | Lee, Sunggun | - |
dc.contributor.author | Kang, Min-Gyu | - |
dc.contributor.author | Nam, Young-Hee | - |
dc.contributor.author | Choi, Jeong-Hee | - |
dc.contributor.author | Yang, Min-Suk | - |
dc.contributor.author | Han, Seung Seok | - |
dc.contributor.author | Lee, Hajeong | - |
dc.contributor.author | Cho, Hyun-Jai | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Jung, Jae Woo | - |
dc.contributor.author | Lee, Kye Hwa | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.date.accessioned | 2022-10-07T00:41:11Z | - |
dc.date.available | 2022-10-07T00:41:11Z | - |
dc.date.created | 2022-09-27 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Clinical and Translational Allergy, Vol.12 No.9, p. e12193 | - |
dc.identifier.issn | 2045-7022 | - |
dc.identifier.uri | https://hdl.handle.net/10371/185534 | - |
dc.description.abstract | Background HLA-B*58:01 is a well-known risk factor for allopurinol-induced severe cutaneous adverse reactions (SCARs). However, only a minority of HLA-B*58:01 carriers suffer SCARs after taking allopurinol. The aim of this study was to investigate subsidiary genetic markers that could identify those at further increased risk of developing allopurinol-induced drug reaction with eosinophilia and systemic symptoms (DRESS) in subjects with HLA-B*58:01. Methods Subjects with B*58:01 were enrolled (21 allopurinol-induced DRESS and 52 allopurinol-tolerant control). HLA-A, -B, -C and -DRB1 alleles were compared. Comparison of risk between HLAs and allopurinol-induced SCAR in separate populations was performed to support the results. Kruskal-Wallis test, Pearson's chi-square test, Fisher's exact test and binary logistic regression were used to analyze the risk of SCAR development. Results Frequencies of A*24:02 (71.4 vs. 17.3%, p < 0.001, odds ratio [OR] = 12.0; 95% confidence interval [CI], 3.6-39.2) were significantly higher in B*58:01 (+) DRESS than B*58:01 (+) tolerant controls. In addition, DRB1*13:02 further increased the risk of DRESS. The phenotype frequency of A*24:02/DRB1*13:02 was significantly higher in the B*58:01 (+) DRESS group than in the B*58:01 (+) tolerant controls (52.4% vs. 5.8%, p < 0.001, OR, 66.0; 95% CI, 6.1-716.2). In 2782 allopurinol user cohort, the overall prevalence of DRESS was 0.22%, which increased to 1.62% and 2.86% in the presence of B*58:01 and B*58:01/A*24:02, respectively. Conclusion The additional secondary screening with A*24:02 and DRB1*13:02 alleles may identify those at further increased risk of allopurinol-induced DRESS in B*58:01 carriers. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | HLA-A24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B58:01 carriers in a Korean population; a multicenter cross-sectional case-control study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/clt2.12193 | - |
dc.citation.journaltitle | Clinical and Translational Allergy | - |
dc.identifier.wosid | 000854031500001 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | e12193 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Hyun-Jai | - |
dc.contributor.affiliatedAuthor | Kim, Yon Su | - |
dc.contributor.affiliatedAuthor | Kang, Hye-Ryun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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