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High low-density lipoprotein cholesterol level is associated with an increased risk of incident early-onset vasomotor symptoms

Cited 1 time in Web of Science Cited 0 time in Scopus
Authors

Choi, Hye Rin; Chang, Yoosoo; Kim, Yejin; Kang, Jeonggyu; Kwon, Min-Jung; Kwon, Ria; Lim, Ga-Young; Kim, Kye-Hyun; Kim, Hoon; Hong, Yun Soo; Zhao, Di; Cho, Juhee; Guallar, Eliseo; Park, Hyun-Young; Ryu, Seungho

Issue Date
2022-08
Publisher
Nature Publishing Group
Citation
Scientific Reports, Vol.12 No.1, p. 14652
Abstract
We investigated the associations between serum lipid profiles and risk of early-onset vasomotor symptoms (VMSs) in premenopausal women. This cohort study comprised 2,540 premenopausal women aged 42-52 years without VMSs at baseline (median follow-up: 4.4 years). VMSs, including hot flashes and night sweats, were assessed using the Menopause-Specific Quality of Life questionnaire (Korean version). Early-onset VMSs were defined as VMSs that occurred premenopause; moderate/severe VMSs were defined as a score of >= 3 points (range: 0 to 6, 6 being most bothersome). Cox proportional hazard regression models were used to estimate hazard ratios with 95% confidence intervals (CI) for the development of VMSs across the lipid levels. Higher low-density lipoprotein (LDL) cholesterol levels were positively associated with increased risk of early-onset VMSs. Compared to the < 100 mg/dL LDL group, the multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for incident VMSs were 1.19 (1.03-1.37) and 1.20 (1.03-1.40) in participants with LDL cholesterol levels of 100-129 mg/dL and >= 130 mg/dL, respectively (P for trend = 0.027). The multivariable-adjusted HR for incident moderate/severe VMSs was 1.37 (95% CI: 1.08-1.73) in participants with LDL >= 130 mg/dL, compared to those with LDL < 100 mg/dL. Meanwhile, triglycerides and total and high-density lipoprotein cholesterol levels were not significantly associated with early-onset VMSs risk in premenopausal women. Premenopausal women with high serum LDL cholesterol concentrations had a higher risk of incident early-onset VMSs. Further studies should confirm our findings and examine whether LDL-lowering interventions reduce the risk of early-onset VMSs among women during menopause transition.
ISSN
2045-2322
URI
https://hdl.handle.net/10371/185720
DOI
https://doi.org/10.1038/s41598-022-19028-4
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