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Longitudinal Analysis of Memory T-Cell Responses in Survivors of Middle East Respiratory Syndrome
DC Field | Value | Language |
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dc.contributor.author | Shin, Hyoung Shik | - |
dc.contributor.author | Kim, Yeonjae | - |
dc.contributor.author | Kang, Jihye | - |
dc.contributor.author | Um, Jihye | - |
dc.contributor.author | Park, Jun Sun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Yeon Sook | - |
dc.contributor.author | Choi, Jae Phil | - |
dc.contributor.author | Rhee, Ji Young | - |
dc.contributor.author | Joh, Joon Sung | - |
dc.contributor.author | Cho, Nam Hyuk | - |
dc.contributor.author | Yang, Jeong Sun | - |
dc.contributor.author | Lee, Joo Yeon | - |
dc.contributor.author | Lim, Dong Gyun | - |
dc.date.accessioned | 2022-10-17T04:16:54Z | - |
dc.date.available | 2022-10-17T04:16:54Z | - |
dc.date.created | 2022-10-14 | - |
dc.date.created | 2022-10-14 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Clinical Infectious Diseases, Vol.75 No.4, pp.596-603 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186159 | - |
dc.description.abstract | © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.BACKGROUND: Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a zoonotic betacoronavirus. The development of effective vaccines and control measures requires a thorough understanding of the immune response to this viral infection. METHODS: We investigated cellular immune responses up to 5 years after infection in a cohort of 59 MERS survivors by performing enzyme-linked immunospot assay and intracellular cytokine staining after stimulation of peripheral blood mononuclear cells with synthetic viral peptides. RESULTS: Memory T-cell responses were detected in 82%, 75%, 69%, 64%, and 64% of MERS survivors from 1-5 years post-infection, respectively. Although the frequency of virus-specific interferon gamma (IFN-γ)-secreting T cells tended to be higher in moderately/severely ill patients than in mildly ill patients during the early period of follow-up, there was no significant difference among the different clinical severity groups across all time points. While both CD4+ and CD8+ T cells were involved in memory T-cell responses, CD4+ T cells persisted slightly longer than CD8+ T cells. Both memory CD4+ and CD8+ T cells recognized the E/M/N proteins better than the S protein and maintained their polyfunctionality throughout the period examined. Memory T-cell responses correlated positively with antibody responses during the initial 3-4 years but not with maximum viral loads at any time point. CONCLUSIONS: These findings advance our understanding of the dynamics of virus-specific memory T-cell immunity after MERS-coronavirus infection, which is relevant to the development of effective T cell-based vaccines. | - |
dc.language | 영어 | - |
dc.publisher | University of Chicago Press | - |
dc.title | Longitudinal Analysis of Memory T-Cell Responses in Survivors of Middle East Respiratory Syndrome | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/cid/ciab1019 | - |
dc.citation.journaltitle | Clinical Infectious Diseases | - |
dc.identifier.wosid | 000789345000001 | - |
dc.identifier.scopusid | 2-s2.0-85138128960 | - |
dc.citation.endpage | 603 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 596 | - |
dc.citation.volume | 75 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hyuk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIBODY-RESPONSE | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | CORONAVIRUS | - |
dc.subject.keywordPlus | SMALLPOX | - |
dc.subject.keywordAuthor | longitudinal analysis | - |
dc.subject.keywordAuthor | memory T cells | - |
dc.subject.keywordAuthor | MERS-CoV | - |
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