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Association of B cell profile and receptor repertoire with the progression of Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | Park, Jong-Chan | - |
dc.contributor.author | Noh, Jinsung | - |
dc.contributor.author | Jang, Sukjin | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Choi, Hayoung | - |
dc.contributor.author | Lee, Dongjoon | - |
dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Chung, Junho | - |
dc.contributor.author | Lee, Dong Young | - |
dc.contributor.author | Lee, Yonghee | - |
dc.contributor.author | Lee, Hyunho | - |
dc.contributor.author | Yoo, Duck Kyun | - |
dc.contributor.author | Lee, Amos Chungwon | - |
dc.contributor.author | Byun, Min Soo | - |
dc.contributor.author | Yi, Dahyun | - |
dc.contributor.author | Han, Sun-Ho | - |
dc.contributor.author | Kwon, Sunghoon | - |
dc.contributor.author | Mook-Jung, Inhee | - |
dc.date.accessioned | 2022-10-18T00:36:42Z | - |
dc.date.available | 2022-10-18T00:36:42Z | - |
dc.date.created | 2022-10-14 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Cell Reports, Vol.40 No.12, p. https://www.sci | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186417 | - |
dc.description.abstract | © 2022 The Author(s)Alzheimer's disease (AD) is the most prevalent type of dementia. Reports have revealed that the peripheral immune system is linked to neuropathology; however, little is known about the contribution of B lymphocytes in AD. For this longitudinal study, 133 participants are included at baseline and second-year follow-up. Also, we analyze B cell receptor (BCR) repertoire data generated from a public dataset of three normal and 10 AD samples and perform BCR repertoire profiling and pairwise sharing analysis. As a result, longitudinal increase in B lymphocytes is associated with increased cerebral amyloid deposition and hyperactivates induced pluripotent stem cell-derived microglia with loss-of-function for beta-amyloid clearance. Patients with AD share similar class-switched BCR sequences with identical isotypes, despite the high somatic hypermutation rate. Thus, BCR repertoire profiling can lead to the development of individualized immune-based therapeutics and treatment. We provide evidence of both quantitative and qualitative changes in B lymphocytes during AD pathogenesis. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Association of B cell profile and receptor repertoire with the progression of Alzheimer's disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.celrep.2022.111391 | - |
dc.citation.journaltitle | Cell Reports | - |
dc.identifier.scopusid | 2-s2.0-85138182580 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | https://www.sci | - |
dc.citation.volume | 40 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Mook-Jung, Inhee | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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