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Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson's Disease Model
DC Field | Value | Language |
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dc.contributor.author | Hong, Dong Geun | - |
dc.contributor.author | Lee, Seulah | - |
dc.contributor.author | Kim, Jaehoon | - |
dc.contributor.author | Yang, Seonguk | - |
dc.contributor.author | Lee, Myunggyo | - |
dc.contributor.author | Ahn, Jinsook | - |
dc.contributor.author | Lee, Haeseung | - |
dc.contributor.author | Chang, Seung-Cheol | - |
dc.contributor.author | Ha, Nam-Chul | - |
dc.contributor.author | Lee, Jaewon | - |
dc.date.accessioned | 2022-10-24T00:20:22Z | - |
dc.date.available | 2022-10-24T00:20:22Z | - |
dc.date.created | 2022-10-07 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | International Journal of Molecular Sciences, Vol.23 No.18, p. 10578 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://hdl.handle.net/10371/186615 | - |
dc.description.abstract | Neurodegenerative diseases such as Parkinson's disease (PD) are known to be related to oxidative stress and neuroinflammation, and thus, modulating neuroinflammation offers a possible means of treating PD-associated pathologies. Morin (2 ',3,4 ',5,7-pentahydroxy flavone) is a flavonol with anti-oxidative and anti-inflammatory effects found in wines, herbs, and fruits. The present study was undertaken to determine whether a morin-containing diet has protective effects in an MPTP-induced mouse model of PD. Mice were fed a control or morin diet for 34 days, and then MPTP (30 mg/kg, i.p.) was administered daily for 5 days to induce a PD-like pathology. We found that dietary morin prevented MPTP-induced motor dysfunction and ameliorated dopaminergic neuronal damage in striatum (STR) and substantia nigra (SN) in our mouse model. Furthermore, MPTP-induced neuroinflammation was significantly reduced in mice fed morin. In vitro studies showed that morin effectively suppressed glial activations in primary microglia and astrocytes, and biochemical analysis and a docking simulation indicated that the anti-inflammatory effects of morin were mediated by blocking the extracellular signal-regulated kinase (ERK)-p65 pathway. These findings suggest that morin effectively inhibits glial activations and has potential use as a functional food ingredient with therapeutic potential for the treatment of PD and other neurodegenerative diseases associated with neuroinflammation. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson's Disease Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms231810578 | - |
dc.citation.journaltitle | International Journal of Molecular Sciences | - |
dc.identifier.wosid | 000858569700001 | - |
dc.identifier.scopusid | 2-s2.0-85138322236 | - |
dc.citation.number | 18 | - |
dc.citation.startpage | 10578 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Ha, Nam-Chul | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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