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Effect of polystyrene nanoplastics and their degraded forms on stem cell fate
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, Gwang-Bum | - |
dc.contributor.author | Kim, Young Geon | - |
dc.contributor.author | Jo, In-Seong | - |
dc.contributor.author | Yoo, Tae Yong | - |
dc.contributor.author | Kim, Sung-Won | - |
dc.contributor.author | Park, Hyun Su | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Yi, Gi-Ra | - |
dc.contributor.author | Bhang, Suk Ho | - |
dc.date.accessioned | 2023-03-20T08:39:58Z | - |
dc.date.available | 2023-03-20T08:39:58Z | - |
dc.date.created | 2022-03-21 | - |
dc.date.created | 2022-03-21 | - |
dc.date.created | 2022-03-21 | - |
dc.date.issued | 2022-05-15 | - |
dc.identifier.citation | Journal of Hazardous Materials, Vol.430, p. 128411 | - |
dc.identifier.issn | 0304-3894 | - |
dc.identifier.uri | https://hdl.handle.net/10371/189445 | - |
dc.description.abstract | Several studies have examined the effects of micro- and nanoplastics on microbes, cells, and the environment. However, only a few studies have examined their effects-especially, those of their reduced cohesiveness-on cell viability and physiology. We synthesized surfactant-free amine-functionalized polystyrene (PS) nanoparticles (NPs) and PS-NPs with decreased crosslinking density (DPS-NPs) without changing other factors, such as size, shape, and zeta potential and examined their effects on cell viability and physiology. PS- and DPS-NPs exhibited reactive oxygen species (ROS) scavenging activity by upregulating GPX3 expression and downregulating HSP70 (ROS-related gene) and XBP1 (endoplasmic reticulum stress-related gene) expression in human bone marrowderived mesenchymal stem cells (hBM-MSCs). Additionally, they led to upregulation of MFN2 (mitochondrial fusion related gene) expression and downregulation of FIS1 (mitochondrial fission related gene) expression, indicating enhanced mitochondrial fusion in hBM-MSCs. Cell-cycle analysis revealed that PS- and DPS-NPs increased the proportion of cells in the S phase, indicating that they promoted cell proliferation and, specifically, the adipogenic differentiation of hBM-MSCs. However, the cytotoxicity of DPS-NPs against hBM-MSCs was higher than that of PS-NPs after long-term treatment under adipogenic conditions. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Effect of polystyrene nanoplastics and their degraded forms on stem cell fate | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jhazmat.2022.128411 | - |
dc.citation.journaltitle | Journal of Hazardous Materials | - |
dc.identifier.wosid | 000762659800001 | - |
dc.identifier.scopusid | 2-s2.0-85124302996 | - |
dc.citation.startpage | 128411 | - |
dc.citation.volume | 430 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | MECHANICAL REGULATION | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DECISION | - |
dc.subject.keywordAuthor | Adipogenic differentiation | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Nanoplastics | - |
dc.subject.keywordAuthor | Polystyrene | - |
dc.subject.keywordAuthor | Reactive oxygen species scavenging | - |
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