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Effect of polystyrene nanoplastics and their degraded forms on stem cell fate

DC Field Value Language
dc.contributor.authorIm, Gwang-Bum-
dc.contributor.authorKim, Young Geon-
dc.contributor.authorJo, In-Seong-
dc.contributor.authorYoo, Tae Yong-
dc.contributor.authorKim, Sung-Won-
dc.contributor.authorPark, Hyun Su-
dc.contributor.authorHyeon, Taeghwan-
dc.contributor.authorYi, Gi-Ra-
dc.contributor.authorBhang, Suk Ho-
dc.date.accessioned2023-03-20T08:39:58Z-
dc.date.available2023-03-20T08:39:58Z-
dc.date.created2022-03-21-
dc.date.created2022-03-21-
dc.date.created2022-03-21-
dc.date.issued2022-05-15-
dc.identifier.citationJournal of Hazardous Materials, Vol.430, p. 128411-
dc.identifier.issn0304-3894-
dc.identifier.urihttps://hdl.handle.net/10371/189445-
dc.description.abstractSeveral studies have examined the effects of micro- and nanoplastics on microbes, cells, and the environment. However, only a few studies have examined their effects-especially, those of their reduced cohesiveness-on cell viability and physiology. We synthesized surfactant-free amine-functionalized polystyrene (PS) nanoparticles (NPs) and PS-NPs with decreased crosslinking density (DPS-NPs) without changing other factors, such as size, shape, and zeta potential and examined their effects on cell viability and physiology. PS- and DPS-NPs exhibited reactive oxygen species (ROS) scavenging activity by upregulating GPX3 expression and downregulating HSP70 (ROS-related gene) and XBP1 (endoplasmic reticulum stress-related gene) expression in human bone marrowderived mesenchymal stem cells (hBM-MSCs). Additionally, they led to upregulation of MFN2 (mitochondrial fusion related gene) expression and downregulation of FIS1 (mitochondrial fission related gene) expression, indicating enhanced mitochondrial fusion in hBM-MSCs. Cell-cycle analysis revealed that PS- and DPS-NPs increased the proportion of cells in the S phase, indicating that they promoted cell proliferation and, specifically, the adipogenic differentiation of hBM-MSCs. However, the cytotoxicity of DPS-NPs against hBM-MSCs was higher than that of PS-NPs after long-term treatment under adipogenic conditions.-
dc.language영어-
dc.publisherElsevier BV-
dc.titleEffect of polystyrene nanoplastics and their degraded forms on stem cell fate-
dc.typeArticle-
dc.identifier.doi10.1016/j.jhazmat.2022.128411-
dc.citation.journaltitleJournal of Hazardous Materials-
dc.identifier.wosid000762659800001-
dc.identifier.scopusid2-s2.0-85124302996-
dc.citation.startpage128411-
dc.citation.volume430-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusPPAR-GAMMA-
dc.subject.keywordPlusADIPOCYTE DIFFERENTIATION-
dc.subject.keywordPlusMECHANICAL REGULATION-
dc.subject.keywordPlusDOWN-REGULATION-
dc.subject.keywordPlusCYCLIN D1-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusGLUTATHIONE-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusDECISION-
dc.subject.keywordAuthorAdipogenic differentiation-
dc.subject.keywordAuthorMesenchymal stem cells-
dc.subject.keywordAuthorNanoplastics-
dc.subject.keywordAuthorPolystyrene-
dc.subject.keywordAuthorReactive oxygen species scavenging-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science

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