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A Therapeutic Nanovaccine that Generates Anti-Amyloid Antibodies and Amyloid-specific Regulatory T Cells for Alzheimer's Disease
DC Field | Value | Language |
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dc.contributor.author | Jung, Mungyo | - |
dc.contributor.author | Lee, Songmin | - |
dc.contributor.author | Park, Sohui | - |
dc.contributor.author | Hong, Jihye | - |
dc.contributor.author | Kim, Cheesue | - |
dc.contributor.author | Cho, Illhwan | - |
dc.contributor.author | Sohn, Hee Su | - |
dc.contributor.author | Kim, Kyunghwan | - |
dc.contributor.author | Park, In Wook | - |
dc.contributor.author | Yoon, Soljee | - |
dc.contributor.author | Kwon, Sungpil | - |
dc.contributor.author | Shin, Jisu | - |
dc.contributor.author | Lee, Donghee | - |
dc.contributor.author | Kang, Mikyung | - |
dc.contributor.author | Go, Seokhyung | - |
dc.contributor.author | Moon, Sangjun | - |
dc.contributor.author | Chung, Yeonseok | - |
dc.contributor.author | Kim, YoungSoo | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2023-04-17T09:21:27Z | - |
dc.date.available | 2023-04-17T09:21:27Z | - |
dc.date.created | 2023-02-14 | - |
dc.date.created | 2023-02-14 | - |
dc.date.created | 2023-02-14 | - |
dc.date.created | 2023-02-14 | - |
dc.date.created | 2023-02-14 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.citation | Advanced Materials, Vol.35 No.3, p. 2207719 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190007 | - |
dc.description.abstract | Alzheimer's disease (AD), the most common cause of dementia, is a complex condition characterized by multiple pathophysiological mechanisms including amyloid-beta (A beta) plaque accumulation and neuroinflammation in the brain. The current immunotherapy approaches, such as anti-A beta monoclonal antibody (mAb) therapy, A beta vaccines, and adoptive regulatory T (Treg) cell transfer, target a single pathophysiological mechanism, which may lead to unsatisfactory therapeutic efficacy. Furthermore, A beta vaccines often induce T helper 1 (Th1) cell-mediated inflammatory responses. Here, a nanovaccine composed of lipid nanoparticles loaded with A beta peptides and rapamycin is developed, which targets multiple pathophysiological mechanisms, exhibits the combined effects of anti-A beta antibody therapy and adoptive A beta-specific Treg cell transfer, and can overcome the limitations of current immunotherapy approaches for AD. The Nanovaccine effectively delivers rapamycin and A beta peptides to dendritic cells, produces both anti-A beta antibodies and A beta-specific Treg cells, removes A beta plaques in the brain, alleviates neuroinflammation, prevents Th1 cell-mediated excessive immune responses, and inhibits cognitive impairment in mice. The nanovaccine shows higher efficacy in cognitive recovery than an A beta vaccine. Unlike anti-A beta mAb therapy and adoptive Treg cell transfer, both of which require complicated and costly manufacturing processes, the nanovaccine is easy-to-prepare and cost-effective. The nanovaccines can represent a novel treatment option for AD. | - |
dc.language | 영어 | - |
dc.publisher | WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.title | A Therapeutic Nanovaccine that Generates Anti-Amyloid Antibodies and Amyloid-specific Regulatory T Cells for Alzheimer's Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adma.202207719 | - |
dc.citation.journaltitle | Advanced Materials | - |
dc.identifier.wosid | 000899749100001 | - |
dc.identifier.scopusid | 2-s2.0-85144317847 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 2207719 | - |
dc.citation.volume | 35 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chung, Yeonseok | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | NANOPARTICLE VACCINES | - |
dc.subject.keywordPlus | REACTIVE ASTROCYTES | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | MENINGOENCEPHALITIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ADUCANUMAB | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | anti-amyloid antibodies | - |
dc.subject.keywordAuthor | antigen-specific regulatory T cells | - |
dc.subject.keywordAuthor | lipid nanoparticles | - |
dc.subject.keywordAuthor | nanovaccines | - |
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