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Longitudinal Analysis of Human Memory T-Cell Response According to the Severity of Illness up to 8 Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
DC Field | Value | Language |
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dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Kim, Gwanghun | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Lee, Chang-Han | - |
dc.contributor.author | Kim, Ik Soo | - |
dc.contributor.author | Jung, Keehoon | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.accessioned | 2023-04-18T06:22:14Z | - |
dc.date.available | 2023-04-18T06:22:14Z | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.citation | Journal of Infectious Diseases, Vol.224 No.1, pp.39-48 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190048 | - |
dc.description.abstract | Background. Understanding the memory T-cell response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for assessing the longevity of protective immunity after SARS-CoV-2 infection or coronavirus disease 2019 (COVID-19) vaccination. However, the longitudinal memory T-cell response up to 8 months post-symptom onset (PSO) according to the severity of illness is unknown. Methods. We analyzed peripheral blood mononuclear cells (PBMCs) from healthy volunteers or patients with COVID-19 who experienced asymptomatic, mild, or severe illness at 2, 5, and 8 months PSO. SARS-CoV-2 spike, nucleocapsid, and membrane protein-stimulated PBMCs were subjected to flow cytometry analysis. Results. A total of 24 patients (7 asymptomatic, 9 with mild disease, and 8 with severe disease) and 6 healthy volunteers were analyzed. SARS-CoV-2-specific OX40(+)CD137(+)CD4(+) T cells and CD69(+)CD137(+)CD8(+) T cells persisted at 8 months PSO. Also, antigen-specific cytokine- producing or polyfunctional CD4(+) T cells were maintained for up to 8 months PSO. Memory CD4(+) T-cell responses tended to be greater in patients who had severe illness than in those with mild or asymptomatic disease. Conclusions. Memory response to SARS-CoV-2, based on the frequency and functionality, persists for 8 months PSO. Further investigations involving its longevity and protective effect from reinfection are warranted. | - |
dc.language | 영어 | - |
dc.publisher | University of Chicago Press | - |
dc.title | Longitudinal Analysis of Human Memory T-Cell Response According to the Severity of Illness up to 8 Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/infdis/jiab159 | - |
dc.citation.journaltitle | Journal of Infectious Diseases | - |
dc.identifier.wosid | 000672776800007 | - |
dc.identifier.scopusid | 2-s2.0-85105563063 | - |
dc.citation.endpage | 48 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 39 | - |
dc.citation.volume | 224 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Nam Joong | - |
dc.contributor.affiliatedAuthor | Lee, Chang-Han | - |
dc.contributor.affiliatedAuthor | Jung, Keehoon | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Sup | - |
dc.contributor.affiliatedAuthor | Shin, Hyun Mu | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | memory response | - |
dc.subject.keywordAuthor | T-cell | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | 8 months | - |
dc.subject.keywordAuthor | severity | - |
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