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Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity
Cited 1 time in
Web of Science
Cited 1 time in Scopus
- Authors
- Issue Date
- 2023-02
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- PHYTOCHEMISTRY, Vol.206
- Abstract
- Natural guanidines, molecules that contain the guanidine moiety, are structurally unique and often exhibit potent biological activities. A phytochemical investigation of the leaves of Alchornea rugosa (Lour.) Mull.Arg. by MS/MS-based molecular networking revealed eight undescribed guanidine-flavanol conjugates named rugonines A-H. The chemical structures of the isolated compounds were comprehensively elucidated by NMR spectroscopy, HRESIMS, and circular dichroism (CD) analysis. All isolated compounds were tested for autophagosome for-mation in HEK293 cells stably expressing GFP-LC3. The results revealed that compounds rugonines D-G showed potential autophagy inhibitory activity.
- ISSN
- 0031-9422
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