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Metabolic Biomarkers In Midtrimester Maternal Plasma Can Accurately Predict Adverse Pregnancy Outcome in Patients with SLE
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Mi | - |
dc.contributor.author | Lee, Eun Mi | - |
dc.contributor.author | Park, Jin Kyun | - |
dc.contributor.author | Jeon, Hae Sun | - |
dc.contributor.author | Oh, Sohee | - |
dc.contributor.author | Hong, Subeen | - |
dc.contributor.author | Jung, Young Mi | - |
dc.contributor.author | Kim, Byoung Jae | - |
dc.contributor.author | Kim, Sun Min | - |
dc.contributor.author | Norwitz, Errol R. | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Louangsenlath, Souphaphone | - |
dc.contributor.author | Park, Chan-Wook | - |
dc.contributor.author | Jun, Jong Kwan | - |
dc.contributor.author | Park, Joong Shin | - |
dc.contributor.author | Lee, Do Yup | - |
dc.date.accessioned | 2023-04-19T00:59:38Z | - |
dc.date.available | 2023-04-19T00:59:38Z | - |
dc.date.created | 2020-01-17 | - |
dc.date.created | 2020-01-17 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Scientific Reports, Vol.9 No.1, p. 15169 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190338 | - |
dc.description.abstract | Patients with systemic lupus erythematosus (SLE) are at increased risk for adverse pregnancy outcome (APO). Accurate prediction of APO is critical to identify, counsel, and manage these high-risk patients. We undertook this study to identify novel biomarkers in mid-trimester maternal plasma to identify pregnant patients with SLE at increased risk of APOs. The study population consisted of pregnant women whose plasma was taken in mid-trimester and available for metabolic signature: (1) SLE and normal pregnancy outcome (Group 1, n =21); (2) SLE with APO (Group 2, n= 12); and (3) healthy pregnant controls (Group 3, n = 10). Mid-trimester maternal plasma was analyzed for integrative profiles of primary metabolite and phospholipid using gas chromatography time-of-flight mass spectrometry (GC-TOF MS) and liquid chromatography Orbitrap mass spectrometry (LC-Orbitrap MS). For performance comparison and validation, plasma samples were analyzed for sFlt-1/PlGF ratio. In the study population, APO developed in 12 of 33 women with SLE (36%). Metabolite profiling of mid-trimester maternal plasma samples identified a total of 327 metabolites using GC-TOF MS and LC-Orbitrap MS. Partial least squares discriminant analysis (PLS-DA) showed clear discrimination among the profiles of SLE groups and healthy pregnant controls (Groups 1/2 vs. 3). Moreover, direct comparison between Groups 1 and 2 demonstrated that 4 primary metabolites and 13 lipid molecules were significantly different. Binary logistic regression analysis suggested a potential metabolic biomarker model that could discriminate Groups 1 and 2. Receiver operating characteristic (ROC) analysis revealed the best predictability for APO with the combination model of two metabolites (LysoPC C22:5 and tryptophan) with AUC of 0.944, comparable to the AUC of sFlt-1/PlGF (AUC 0.857). In conclusion, metabolic biomarkers in mid-trimester maternal plasma can accurately predict APO in patients with SLE. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Metabolic Biomarkers In Midtrimester Maternal Plasma Can Accurately Predict Adverse Pregnancy Outcome in Patients with SLE | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-019-51285-8 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000491858600001 | - |
dc.identifier.scopusid | 2-s2.0-85074093181 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 15169 | - |
dc.citation.volume | 9 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Jin Kyun | - |
dc.contributor.affiliatedAuthor | Kim, Sun Min | - |
dc.contributor.affiliatedAuthor | Lee, Eun Bong | - |
dc.contributor.affiliatedAuthor | Park, Chan-Wook | - |
dc.contributor.affiliatedAuthor | Jun, Jong Kwan | - |
dc.contributor.affiliatedAuthor | Park, Joong Shin | - |
dc.contributor.affiliatedAuthor | Lee, Do Yup | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELL ACTIVATION | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | MS | - |
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