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A short C-terminal tail prevents mis-targeting of hydrophobic mitochondrial membrane proteins to the ER

Cited 2 time in Web of Science Cited 3 time in Scopus
Authors

Reithinger, Johannes H.; Yim, Chewon; Park, Kwangjin; Bjorkholm, Patrik; von Heijne, Gunnar; Kim, Hyun

Issue Date
2013-11
Publisher
Elsevier BV
Citation
FEBS Letters, Vol.587 No.21, pp.3480-3486
Abstract
Sdh3/Shh3, a subunit of mitochondrial succinate dehydrogenase, contains transmembrane domains with a hydrophobicity comparable to that of endoplasmic reticulum (ER) proteins. Here, we show that a C-terminal reporter fusion to Sdh3/Shh3 results in partial mis-targeting of the protein to the ER. This mis-targeting is mediated by the signal recognition particle (SRP) and depends on the length of the C-terminal tail. These results imply that if nuclear-encoded mitochondrial proteins contain strongly hydrophobic transmembrane domains and a long C-terminal tail, they have the potential to be recognized by SRP and mis-targeted to the ER. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
ISSN
0014-5793
URI
https://hdl.handle.net/10371/190846
DOI
https://doi.org/10.1016/j.febslet.2013.08.041
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