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A short C-terminal tail prevents mis-targeting of hydrophobic mitochondrial membrane proteins to the ER
Cited 2 time in
Web of Science
Cited 3 time in Scopus
- Authors
- Issue Date
- 2013-11
- Publisher
- Elsevier BV
- Citation
- FEBS Letters, Vol.587 No.21, pp.3480-3486
- Abstract
- Sdh3/Shh3, a subunit of mitochondrial succinate dehydrogenase, contains transmembrane domains with a hydrophobicity comparable to that of endoplasmic reticulum (ER) proteins. Here, we show that a C-terminal reporter fusion to Sdh3/Shh3 results in partial mis-targeting of the protein to the ER. This mis-targeting is mediated by the signal recognition particle (SRP) and depends on the length of the C-terminal tail. These results imply that if nuclear-encoded mitochondrial proteins contain strongly hydrophobic transmembrane domains and a long C-terminal tail, they have the potential to be recognized by SRP and mis-targeted to the ER. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
- ISSN
- 0014-5793
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