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Application of Base Editor-Mediated Genome Editing in Mouse Retina
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- Authors
- Issue Date
- 2023-01
- Publisher
- Humana Press, Inc.
- Citation
- Methods in molecular biology (Clifton, N.J.), Vol.2606, pp.179-188
- Abstract
- Base editor is a newly developed genome editing technology that enables conversion of single nucleotides without DNA double-strand breaks (DSB) and maintains a low rate of insertion-deletion (INDEL) errors. With these flexibility and safety, base editor has been widely used in many fields, including inherited retinal disease. The majority of retinal genome editing requires intravitreal and subretinal injection delivery of the therapeutic vector in order to transduce the target cells. Here, we provide an application guide of base editor as performed in the mouse retina.
- ISSN
- 1064-3745
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