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A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response
DC Field | Value | Language |
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dc.contributor.author | Luo, Yang | - |
dc.contributor.author | Kanai, Masahiro | - |
dc.contributor.author | Choi, Wanson | - |
dc.contributor.author | Li, Xinyi | - |
dc.contributor.author | Sakaue, Saori | - |
dc.contributor.author | Yamamoto, Kenichi | - |
dc.contributor.author | Ogawa, Kotaro | - |
dc.contributor.author | Gutierrez-Arcelus, Maria | - |
dc.contributor.author | Gregersen, Peter K. | - |
dc.contributor.author | Stuart, Philip E. | - |
dc.contributor.author | Elder, James T. | - |
dc.contributor.author | Forer, Lukas | - |
dc.contributor.author | Schoenherr, Sebastian | - |
dc.contributor.author | Fuchsberger, Christian | - |
dc.contributor.author | Smith, Albert V. | - |
dc.contributor.author | Fellay, Jacques | - |
dc.contributor.author | Carrington, Mary | - |
dc.contributor.author | Haas, David W. | - |
dc.contributor.author | Guo, Xiuqing | - |
dc.contributor.author | Palmer, Nicholette D. | - |
dc.contributor.author | Chen, Yii-Der Ida | - |
dc.contributor.author | Rotter, Jerome I. | - |
dc.contributor.author | Taylor, Kent D. | - |
dc.contributor.author | Rich, Stephen S. | - |
dc.contributor.author | Correa, Adolfo | - |
dc.contributor.author | Wilson, James G. | - |
dc.contributor.author | Kathiresan, Sekar | - |
dc.contributor.author | Cho, Michael H. | - |
dc.contributor.author | Metspalu, Andres | - |
dc.contributor.author | Esko, Tonu | - |
dc.contributor.author | Okada, Yukinori | - |
dc.contributor.author | Han, Buhm | - |
dc.contributor.author | McLaren, Paul J. | - |
dc.contributor.author | Raychaudhuri, Soumya | - |
dc.date.accessioned | 2023-04-25T07:30:20Z | - |
dc.date.available | 2023-04-25T07:30:20Z | - |
dc.date.created | 2021-10-21 | - |
dc.date.created | 2021-10-21 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.citation | Nature Genetics, Vol.53 No.10, pp.1504-1516 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191473 | - |
dc.description.abstract | A high-resolution reference panel based on whole-genome sequencing data enables accurate imputation of HLA alleles across diverse populations and fine-mapping of HLA association signals for HIV-1 host response. Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts, particularly in the MHC, which has population-specific structure. To enable such studies, we constructed a large (n = 21,546) HLA reference panel spanning five global populations based on whole-genome sequences. Despite population-specific long-range haplotypes, we demonstrated accurate imputation at G-group resolution (94.2%, 93.7%, 97.8% and 93.7% in admixed African (AA), East Asian (EAS), European (EUR) and Latino (LAT) populations). Applying HLA imputation to genome-wide association study data for HIV-1 viral load in three populations (EUR, AA and LAT), we obviated effects of previously reported associations from population-specific HIV studies and discovered a novel association at position 156 in HLA-B. We pinpointed the MHC association to three amino acid positions (97, 67 and 156) marking three consecutive pockets (C, B and D) within the HLA-B peptide-binding groove, explaining 12.9% of trait variance. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41588-021-00935-7 | - |
dc.citation.journaltitle | Nature Genetics | - |
dc.identifier.wosid | 000703962800011 | - |
dc.identifier.scopusid | 2-s2.0-85116750590 | - |
dc.citation.endpage | 1516 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1504 | - |
dc.citation.volume | 53 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Han, Buhm | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POLYGENIC RISK SCORES | - |
dc.subject.keywordPlus | GENETIC-BASIS | - |
dc.subject.keywordPlus | AMINO-ACID | - |
dc.subject.keywordPlus | HAPLOTYPES | - |
dc.subject.keywordPlus | ALLELES | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | LOCI | - |
dc.subject.keywordPlus | MHC | - |
dc.subject.keywordPlus | MICROPOLYMORPHISM | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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