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Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong Ha | - |
dc.contributor.author | Kim, HyeongRyul | - |
dc.contributor.author | Choi, Yun Jung | - |
dc.contributor.author | Kim, Seon Ye | - |
dc.contributor.author | Lee, Jung-Eun | - |
dc.contributor.author | Sung, Ki Jung | - |
dc.contributor.author | Sung, Young Hoon | - |
dc.contributor.author | Packd, Chan-Gi | - |
dc.contributor.author | Jung, Min-kyo | - |
dc.contributor.author | Han, Buhm | - |
dc.contributor.author | Kim, Kunhee | - |
dc.contributor.author | Kim, Woo Sung | - |
dc.contributor.author | Nam, Soo Jeong | - |
dc.contributor.author | Choi, Chang-Min | - |
dc.contributor.author | Yun, Miyong | - |
dc.contributor.author | Lee, Jae Cheol | - |
dc.contributor.author | Rho, Jin Kyung | - |
dc.date.accessioned | 2023-04-25T07:31:37Z | - |
dc.date.available | 2023-04-25T07:31:37Z | - |
dc.date.created | 2020-04-10 | - |
dc.date.created | 2020-04-10 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Experimental and Molecular Medicine, Vol.51 No.8, p. 94 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191501 | - |
dc.description.abstract | Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded clinical benefits in several types of cancer, further studies are required to clarify predictive biomarkers for drug efficacy and to understand the fundamental mechanism of PD-1/PD-L1 interaction between host and tumor cells. Here, we show that exosomes derived from lung cancer cells express PD-L1 and play a role in immune escape by reducing T-cell activity and promoting tumor growth. The abundance of PD-L1 on exosomes represented the quantity of PD-L1 expression on cell surfaces. Exosomes containing PD-L1 inhibited interferon-gamma (IFN-gamma) secretion by Jurkat T cells. IFN-gamma secretion was restored by PD-L1 knockout or masking on the exosomes. Both forced expression of PD-L1 on cells without PD-L1 and treatment with exosomes containing PD-L1 enhanced tumor growth in vivo. PD-L1 was present on exosomes isolated from the plasma of patients with non-small cell lung cancer, and its abundance in exosomes was correlated with PD-L1 positivity in tumor tissues. Exosomes can impair immune functions by reducing cytokine production and inducing apoptosis in CD8(+) T cells. Our findings indicate that tumor-derived exosomes expressing PD-L1 may be an important mediator of tumor immune escape. | - |
dc.language | 영어 | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s12276-019-0295-2 | - |
dc.citation.journaltitle | Experimental and Molecular Medicine | - |
dc.identifier.wosid | 000480660300001 | - |
dc.identifier.scopusid | 2-s2.0-85070366659 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 94 | - |
dc.citation.volume | 51 | - |
dc.identifier.kciid | ART002498919 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Han, Buhm | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | TARGETED THERAPY | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | MICROVESICLES | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | BLOCKADE | - |
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