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Bispecific anti-mPDGFR beta x cotinine scFv-C-kappa-scFv fusion protein and cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert cytotoxicity against mPDGFR beta expressing cells

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dc.contributor.authorKim, Soohyun-
dc.contributor.authorKim, Hyori-
dc.contributor.authorJo, Dong Hyun-
dc.contributor.authorKim, Jeong Hun-
dc.contributor.authorKim, Su Ree-
dc.contributor.authorKang, Dongmin-
dc.contributor.authorHwang, Dobeen-
dc.contributor.authorChung, Junho-
dc.date.accessioned2023-04-25T07:31:54Z-
dc.date.available2023-04-25T07:31:54Z-
dc.date.created2019-11-29-
dc.date.created2019-11-29-
dc.date.issued2019-02-
dc.identifier.citationMethods, Vol.154, pp.125-135-
dc.identifier.issn1046-2023-
dc.identifier.urihttps://hdl.handle.net/10371/191507-
dc.description.abstractAntibody selection for antibody-drug conjugates (ADCs) has traditionally depended on its internalization into the target cell, although ADC efficacy also relies on recycling of the receptor-ADC complex, endo-lysosomal trafficking, and subsequent linker/antibody proteolysis. In this study, we observed that a bispecific anti-murine platelet-derived growth factor receptor beta (mPDGFR beta) x cotinine single-chain variable fragment (scFv)-kappa constant region (C-kappa)-scFv fusion protein and cotinine-duocarmycin can form an ADC-like complex to induce cytotoxicity against rnPDGFR beta expressing cells. Multiple anti-mPDGFR beta antibody candidates can be produced in this bispecific scFv-C-kappa-scFv fusion protein format and tested for their ability to deliver cotinine-conjugated cytotoxic drugs, thus providing an improved approach for antibody selection in ADC development.-
dc.language영어-
dc.publisherAcademic Press-
dc.titleBispecific anti-mPDGFR beta x cotinine scFv-C-kappa-scFv fusion protein and cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert cytotoxicity against mPDGFR beta expressing cells-
dc.typeArticle-
dc.identifier.doi10.1016/j.ymeth.2018.10.002-
dc.citation.journaltitleMethods-
dc.identifier.wosid000457813100015-
dc.identifier.scopusid2-s2.0-85054685647-
dc.citation.endpage135-
dc.citation.startpage125-
dc.citation.volume154-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorJo, Dong Hyun-
dc.contributor.affiliatedAuthorKim, Jeong Hun-
dc.contributor.affiliatedAuthorChung, Junho-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusGROWTH-FACTOR RECEPTOR-
dc.subject.keywordPlusINTRACELLULAR TRAFFICKING-
dc.subject.keywordPlusMONOCLONAL-ANTIBODY-
dc.subject.keywordPlusPDGF RECEPTORS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusINTERNALIZATION-
dc.subject.keywordPlusAFFINITY-
dc.subject.keywordPlusENDOCYTOSIS-
dc.subject.keywordPlusDOXORUBICIN-
dc.subject.keywordPlusXENOGRAFTS-
dc.subject.keywordAuthorAntibody-drug conjugate-
dc.subject.keywordAuthorBispecific antibody-
dc.subject.keywordAuthorCotinine-
dc.subject.keywordAuthorDuocarmycin-
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