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Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Hyun Beom | - |
dc.contributor.author | Wi, Jung-Sub | - |
dc.contributor.author | Jo, Dong Hyun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Lee, Sang-Won | - |
dc.contributor.author | Lee, Tae Geol | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.date.accessioned | 2023-04-25T07:32:54Z | - |
dc.date.available | 2023-04-25T07:32:54Z | - |
dc.date.created | 2018-09-12 | - |
dc.date.created | 2018-09-12 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Nanomedicine: Nanotechnology, Biology, and Medicine, Vol.13 No.6, pp.1901-1911 | - |
dc.identifier.issn | 1549-9634 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191529 | - |
dc.description.abstract | Bare gold nanospheres have been shown to have anti-angiogenic effects but are optically unfavorable because their resonant wavelength lies in the visible spectrum. Here, we design gold nanodisks with a higher scattering capability than gold nanorods and with a resonant wavelength at near-infrared region -the area where the source of light utilized by optical coherence tomography (OCT) lies. With a physical synthesis system, we then fabricate 160-nm-sized gold nanodisks exhibiting resonant wavelength at 830 nm. The synthesized nanoparticles were successfully visualized in in vivo OCT at concentrations as low as 1 pM. After demonstrating their binding ability to vascular endothelial growth factor (VEGF), we show that they suppress VEGF-induced migration of endothelial cells. Finally, we demonstrate that intravitreally injected gold nanodisks attenuate neovascularization of oxygen-induced retinopathy in mice, in a dose dependent manner, such that they are cleared from the vitreous within 2 weeks without histologic or electrophysiologic toxicity. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.nano.2017.03.016 | - |
dc.citation.journaltitle | Nanomedicine: Nanotechnology, Biology, and Medicine | - |
dc.identifier.wosid | 000406618700006 | - |
dc.identifier.scopusid | 2-s2.0-85020818730 | - |
dc.citation.endpage | 1911 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 1901 | - |
dc.citation.volume | 13 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jo, Dong Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OXYGEN-INDUCED RETINOPATHY | - |
dc.subject.keywordPlus | PATHOLOGICAL ANGIOGENESIS | - |
dc.subject.keywordPlus | INTRAVITREAL INJECTION | - |
dc.subject.keywordPlus | SURFACE-CHARGE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | NANORODS | - |
dc.subject.keywordPlus | SHAPE | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordAuthor | Gold nanodisk | - |
dc.subject.keywordAuthor | Near-infrared | - |
dc.subject.keywordAuthor | Optical coherence tomography | - |
dc.subject.keywordAuthor | Intraocular application | - |
dc.subject.keywordAuthor | Angiogenesis inhibitor | - |
dc.subject.keywordAuthor | Retinal neovascularization | - |
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