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Signal transducer and activator of transcription 3 (Stat3) contributes to T-cell homeostasis by regulating pro-survival Bcl-2 family genes

Cited 28 time in Web of Science Cited 26 time in Scopus
Authors

Lee, Jin-Ku; Won, Cheolhee; Yi, Eun Hee; Seok, Seung-Hyeok; Kim, Myoung-Hwan; Kim, Sang-Jeong; Chung, Myung-Hee; Lee, Hyun Gyu; Ikuta, Koichi; Ye, Sang-Kyu

Issue Date
2013-11
Publisher
Blackwell Publishing Inc.
Citation
Immunology, Vol.140 No.3, pp.288-300
Abstract
The naive T-cell pool in peripheral lymphoid tissues is fairly stable in terms of number, diversity and functional capabilities in spite of the absence of prominent stimuli. This stability is attributed to continuous tuning of the composition of the T-cell pool by various homeostatic signals. Despite extensive research into the link between signal transducer and activator of transcription 3 (Stat3) and T-cell survival, little is known about how Stat3 regulates homeostasis by maintaining the required naive T-cell population in peripheral lymphoid organs. We assessed whether the elimination of Stat3 in T cells limits T-cell survival. We demonstrated that the proportion and number of single-positive thymocytes as well as T cells in the spleen and lymph nodes were significantly decreased in the Stat3-deficient group as a result of the enhanced susceptibility of Stat3-deleted T lymphocytes to apoptosis. Importantly, expression of the anti-apoptotic Bcl-2 and Bcl-xL was markedly decreased in Stat3-deleted single-positive thymocytes and T lymphocytes, suggesting that Stat3 helps to maintain the T-cell pool in the resting condition by promoting the expression of Bcl-2 family genes. These findings suggest the importance of Stat3 in the integration of homeostatic cues for the maintenance and functional tuning of the T-cell pool.
ISSN
0019-2805
URI
https://hdl.handle.net/10371/191557
DOI
https://doi.org/10.1111/imm.12133
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