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CK20 Expression Enhances the Invasiveness of Tamoxifen-resistant MCF-7 Cells
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Min, Yun Sook | - |
| dc.contributor.author | Yi, Eun Hee | - |
| dc.contributor.author | Lee, Jin-Ku | - |
| dc.contributor.author | Choi, Ji Won | - |
| dc.contributor.author | Sim, Ji Hyun | - |
| dc.contributor.author | Kang, Jae-Seung | - |
| dc.contributor.author | Kim, Yong-Nyun | - |
| dc.contributor.author | Juhnn, Yong-Sung | - |
| dc.contributor.author | Kim, Hang-Rae | - |
| dc.contributor.author | Ye, Sang-Kyu | - |
| dc.date.accessioned | 2023-04-26T05:07:45Z | - |
| dc.date.available | 2023-04-26T05:07:45Z | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.issued | 2012-04 | - |
| dc.identifier.citation | Anticancer Research, Vol.32 No.4, pp.1221-1228 | - |
| dc.identifier.issn | 0250-7005 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/191566 | - |
| dc.description.abstract | Cytokeratin 20 (CK20) is an intermediate filament that is known to be a prognostic marker in several types of cancer. However, little is known about CK20 expression and tumor metastasis in tamoxifen-resistant MCF-7 (TRM-7) breast cancer cells. TRM-7 cells overexpress CK20, resulting in enhanced invasiveness in vitro. CK20 silencing reduced the invasiveness of TRM-7 cells. Moreover, CK20 expression in MCF-7 cells was regulated by peroxisome proliferator-activated receptor gamma (PPAR gamma). Our findings suggest that PPAR gamma-dependent CK20 expression enhances the metastatic potential of MCF-7 breast cancer cells and may be a potential therapeutic target in tamoxifen-resistant breast cancer. | - |
| dc.language | 영어 | - |
| dc.publisher | International Institute of Anticancer Research | - |
| dc.title | CK20 Expression Enhances the Invasiveness of Tamoxifen-resistant MCF-7 Cells | - |
| dc.type | Article | - |
| dc.citation.journaltitle | Anticancer Research | - |
| dc.identifier.wosid | 000302492600012 | - |
| dc.identifier.scopusid | 2-s2.0-84859996800 | - |
| dc.citation.endpage | 1228 | - |
| dc.citation.number | 4 | - |
| dc.citation.startpage | 1221 | - |
| dc.citation.volume | 32 | - |
| dc.description.isOpenAccess | N | - |
| dc.contributor.affiliatedAuthor | Lee, Jin-Ku | - |
| dc.contributor.affiliatedAuthor | Kang, Jae-Seung | - |
| dc.contributor.affiliatedAuthor | Juhnn, Yong-Sung | - |
| dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
| dc.contributor.affiliatedAuthor | Ye, Sang-Kyu | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
| dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
| dc.subject.keywordPlus | POLYMERASE CHAIN-REACTION | - |
| dc.subject.keywordPlus | CYTOKERATIN 20 EXPRESSION | - |
| dc.subject.keywordPlus | INTERMEDIATE-FILAMENTS | - |
| dc.subject.keywordPlus | COLORECTAL-CANCER | - |
| dc.subject.keywordPlus | UROTHELIAL CELLS | - |
| dc.subject.keywordPlus | MARKER | - |
| dc.subject.keywordPlus | GROWTH | - |
| dc.subject.keywordPlus | DIFFERENTIATION | - |
| dc.subject.keywordAuthor | Tamoxifen-resistant breast cancer cells | - |
| dc.subject.keywordAuthor | cytokeratin 20 | - |
| dc.subject.keywordAuthor | tumor invasiveness | - |
| dc.subject.keywordAuthor | peroxisome proliferator-activated receptor gamma (PPAR gamma) | - |
| dc.subject.keywordAuthor | MCF-7 | - |
| dc.subject.keywordAuthor | TRM-7 cells | - |
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