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Nuclear expression of p53 in mature tumor endothelium of retinoblastoma

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors

Lee, Byung Joo; Kim, Jin Hyoung; Jo, Dong Hyun; Kim, Kyu-Won; Yu, Young Suk; Kim, Jeong Hun

Issue Date
2014-01
Publisher
SPANDIDOS PUBL LTD
Citation
ONCOLOGY REPORTS, Vol.32 No.2, pp.801-807
Abstract
The present study aimed to investigate the p53 expression pattern in tumor cells and in mature tumor vascular endothelium of retinoblastoma. Nuclear p53 accumulation was observed in most of the tumor cells in both the human and orthotopic retinoblastoma animal models using SNUOT-Rb1 and Y79 cells. In the orthotopic animal model, some of the tumor vascular endothelium also demonstrated nuclear p53 immunoreactivity, and the ratio of p53 positivity among the total mature tumor vascular endothelium was slightly higher in the Y79 cell model when compared with the SNUOT-Rb1 cell model. In addition, in the human retinoblastoma specimens, 32.9% of the tumor vascular endothelium showed p53 nuclear staining. In conclusion, some of the mature tumor vascular endothelium in both the human and orthotopic models of retinoblastoma share the same cytogenetic abnormality (an abnormal nuclear accumulation of p53) with retinoblastoma cells.
ISSN
1021-335X
URI
https://hdl.handle.net/10371/191615
DOI
https://doi.org/10.3892/or.2014.3236
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