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NK Cell-associated Antigen Expression in Retinoblastoma Animal Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun Kyoung | - |
dc.contributor.author | Jo, Dong Hyun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.date.accessioned | 2023-04-26T05:12:07Z | - |
dc.date.available | 2023-04-26T05:12:07Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | CANCER INVESTIGATION, Vol.31 No.1, pp.72-78 | - |
dc.identifier.issn | 0735-7907 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191634 | - |
dc.description.abstract | Natural killer (NK) cells are critical components of our immune system. Herein, we for the first time analyzed the expression and localization of the activating receptor NK cell lectin-like receptor gene 2D (NKG2D) ligands, HLA-G, MICA, MICA/B, and ULBP-2 in orthotopic transplantation models of retinoblastoma. Interestingly, HLA-G and MICA/B were expressed in retinoblastoma cell, whereas MICA and ULBP-2 were not detected. Moreover, HLA-G and MICA/Bwere primarily detected in proliferative area of the tumor periphery with high Ki-67 immunostaining. Our results suggest that NKG2D ligands are differentially expressed in retinoblastoma, which would play a crucial role in immunomodulation in retinoblastoma. | - |
dc.language | 영어 | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.title | NK Cell-associated Antigen Expression in Retinoblastoma Animal Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3109/07357907.2012.743554 | - |
dc.citation.journaltitle | CANCER INVESTIGATION | - |
dc.identifier.wosid | 000313679200010 | - |
dc.identifier.scopusid | 2-s2.0-84872714123 | - |
dc.citation.endpage | 78 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 72 | - |
dc.citation.volume | 31 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jo, Dong Hyun | - |
dc.contributor.affiliatedAuthor | Yu, Young Suk | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CHROMOSOME REGION 6P21 | - |
dc.subject.keywordPlus | I ALTERED PHENOTYPES | - |
dc.subject.keywordPlus | G UP-REGULATION | - |
dc.subject.keywordPlus | HLA-G | - |
dc.subject.keywordPlus | CANCER PATIENTS | - |
dc.subject.keywordPlus | HIGH-FREQUENCY | - |
dc.subject.keywordPlus | NKG2D LIGANDS | - |
dc.subject.keywordPlus | INHIBITORY RECEPTOR | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordAuthor | HLA-G | - |
dc.subject.keywordAuthor | MICA/B | - |
dc.subject.keywordAuthor | NKG2D | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Retinoblastoma | - |
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