Publications

Detailed Information

Differential Profiles of MicroRNAs in Retinoblastoma Cell Lines of Different Proliferation and Adherence Patterns

DC Field Value Language
dc.contributor.authorJo, Dong Hyun-
dc.contributor.authorKim, Jin Hyoung-
dc.contributor.authorPark, Woong-Yang-
dc.contributor.authorKim, Kyu-Won-
dc.contributor.authorYu, Young Suk-
dc.contributor.authorKim, Jeong Hun-
dc.date.accessioned2023-04-26T05:12:34Z-
dc.date.available2023-04-26T05:12:34Z-
dc.date.created2017-11-15-
dc.date.created2017-11-15-
dc.date.created2017-11-15-
dc.date.created2017-11-15-
dc.date.issued2011-10-
dc.identifier.citationJOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, Vol.33 No.7, pp.529-533-
dc.identifier.issn1077-4114-
dc.identifier.urihttps://hdl.handle.net/10371/191644-
dc.description.abstractRetinoblastoma (RB) is the most common intraocular malignant tumor in childhood. To investigate differential expression of microRNAs (miRNAs) in RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth, miRNA microarray was performed. Common mRNA targets of each miRNA were extracted from 4 web-based databases: TargetScan, miRanda, RNAhybrid, and PicTar. Biological functions of target genes were predicted with the PANTHER Classification System. We identified 39 differentially expressed miRNAs between 2 cell lines: 22 were upregulated in SNUOT-Rb1 cells, and the other 17 were overexpressed in Y79 cells. More than half of top 10 mRNA targets of hsa-miR-10b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, and hsa-let-7c in SNUOT-Rb1 cells and hsa-miR-34a, hsa-miR-34c-5p, hsa-miR-124, hsa-miR-135b, hsa-miR-142-5p, and hsa-let-7i in Y79 cells were related with biological processes, which could affect the growth patterns of cells: cell adhesion, cell cycle, cell death, and cell division. On the basis of the data from the target analysis of each miRNA, we found out several miRNAs, which were differentially expressed and had targets of possible impact on progression of RB. From these analyses, we suggest that some differential miRNAs could have roles in miRNA-targeted treatments on RB.-
dc.language영어-
dc.publisherLIPPINCOTT WILLIAMS & WILKINS-
dc.titleDifferential Profiles of MicroRNAs in Retinoblastoma Cell Lines of Different Proliferation and Adherence Patterns-
dc.typeArticle-
dc.identifier.doi10.1097/MPH.0b013e318228280a-
dc.citation.journaltitleJOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY-
dc.identifier.wosid000295157900026-
dc.identifier.scopusid2-s2.0-80053308600-
dc.citation.endpage533-
dc.citation.number7-
dc.citation.startpage529-
dc.citation.volume33-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorJo, Dong Hyun-
dc.contributor.affiliatedAuthorYu, Young Suk-
dc.contributor.affiliatedAuthorKim, Jeong Hun-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusN-MYC AMPLIFICATION-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusHYBRIDIZATION-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusFAMILY-
dc.subject.keywordPlusROLES-
dc.subject.keywordAuthoradhesion-
dc.subject.keywordAuthormicroRNA-
dc.subject.keywordAuthorproliferation-
dc.subject.keywordAuthorretinoblastoma cell line-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

  • College of Medicine
  • Department of Medicine
Research Area

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share