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Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation
DC Field | Value | Language |
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dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Ko, Jung Hwa | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Kim, Youngji | - |
dc.contributor.author | Park, Chan-Sik | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.date.accessioned | 2023-04-26T08:09:05Z | - |
dc.date.available | 2023-04-26T08:09:05Z | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | Xenotransplantation, Vol.16 No.2, pp.74-82 | - |
dc.identifier.issn | 0908-665X | - |
dc.identifier.uri | https://hdl.handle.net/10371/191683 | - |
dc.description.abstract | Oh JY, Kim MK, Ko JH, Lee HJ, Kim Y, Park C-S, Park C-G, Kim SJ, Wee WR, Lee JH. Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation 2009; 16: 74-82. (C) 2009 John Wiley & Sons A/S. To investigate the role of T cells and natural killer (NK) cells in mediating corneal xenograft rejection in a pig-to-mouse model. Pig corneas were orthotopically transplanted into BALB/c, C57BL/6, nude, severe combined immunodeficiency (SCID), and NOD/SCID/gamma c(null) (NOG) mice. Graft survival was clinically assessed by slit-lamp biomicroscopy and median survival times (MST) were calculated. The rejected grafts were histologically evaluated using antibodies against CD4, CD8, NK1.1, and F4/80. The pig corneal xenografts were acutely rejected by BALB/c and C57BL/6 mice (MST 9.0 days), while nude, SCID and NOG mice rejected pig corneas in a more delayed fashion (MST 16.0, 16.4, and 16.9 days, respectively). The majority of infiltrating cells found in rejected grafts in C57BL/6 mice were macrophages and CD4(+) T cells, while CD8(+) T cells and NK cells were rarely found. The grafts in nude mice had markedly decreased inflammatory infiltration with small numbers of macrophages and CD4(+) T cells. Infiltration was even more modest in grafts in SCID and NOG mice. T cells play an important role in acute rejection of pig corneal xenografts in mice, although acute rejection is not solely the result of T-cell-mediated immunity. NK cells are less likely to be involved in the rejection process. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1399-3089.2009.00514.x | - |
dc.citation.journaltitle | Xenotransplantation | - |
dc.identifier.wosid | 000265433400005 | - |
dc.identifier.scopusid | 2-s2.0-65349160408 | - |
dc.citation.endpage | 82 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 74 | - |
dc.citation.volume | 16 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.contributor.affiliatedAuthor | Kim, Mee Kum | - |
dc.contributor.affiliatedAuthor | Park, Chung-Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Sang Joon | - |
dc.contributor.affiliatedAuthor | Wee, Won Ryang | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PORCINE CORNEA | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | XENOGRAFT | - |
dc.subject.keywordAuthor | cornea | - |
dc.subject.keywordAuthor | mouse | - |
dc.subject.keywordAuthor | pig | - |
dc.subject.keywordAuthor | rejection | - |
dc.subject.keywordAuthor | xenotransplantation | - |
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