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Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bang, Ye-Ji | - |
dc.contributor.author | Hu, Zehan | - |
dc.contributor.author | Li, Yun | - |
dc.contributor.author | Gattu, Sureka | - |
dc.contributor.author | Ruhn, Kelly A. | - |
dc.contributor.author | Raj, Prithvi | - |
dc.contributor.author | Herz, Joachim | - |
dc.contributor.author | Hooper, Lora, V | - |
dc.date.accessioned | 2023-05-03T05:44:35Z | - |
dc.date.available | 2023-05-03T05:44:35Z | - |
dc.date.created | 2022-09-13 | - |
dc.date.created | 2022-09-13 | - |
dc.date.created | 2022-09-13 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | SCIENCE, Vol.373 No.6561, pp.abf9232-+ | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191769 | - |
dc.description.abstract | Vitamin A and its derivative retinol are essential for the development of intestinal adaptive immunity. Retinoic acid (RA)-producing myeloid cells are central to this process, but how myeloid cells acquire retinol for conversion to RA is unknown. Here, we show that serum amyloid A (SAA) proteins-retinol-binding proteins induced in intestinal epithelial cells by the microbiota-deliver retinol to myeloid cells. We identify low-density lipoprotein (LDL) receptor-related protein 1 (LRP1) as an SAA receptor that endocytoses SAA-retinol complexes and promotes retinol acquisition by RA-producing intestinal myeloid cells. Consequently, SAA and LRP1 are essential for vitamin A-dependent immunity, including B and T cell homing to the intestine and immunoglobulin A production. Our findings identify a key mechanism by which vitamin A promotes intestinal immunity. | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/science.abf9232 | - |
dc.citation.journaltitle | SCIENCE | - |
dc.identifier.wosid | 000697488600056 | - |
dc.identifier.scopusid | 2-s2.0-85115177902 | - |
dc.citation.endpage | + | - |
dc.citation.number | 6561 | - |
dc.citation.startpage | abf9232 | - |
dc.citation.volume | 373 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Bang, Ye-Ji | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MEDIATES CELLULAR UPTAKE | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | MICROSCALE THERMOPHORESIS | - |
dc.subject.keywordPlus | DENDRITIC CELL | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | TH17 | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | RESPONSES | - |
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