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Active maintenance of endothelial cells prevents kidney fibrosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Seung Hee | - |
dc.contributor.author | Kim, Yong Chul | - |
dc.contributor.author | An, Jung Nam | - |
dc.contributor.author | Kim, Jin Hyuk | - |
dc.contributor.author | Lee, Juhoh | - |
dc.contributor.author | Lee, Hee-Yoon | - |
dc.contributor.author | Cho, Joo-Youn | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Oh, Yun Kyu | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Lee, Jung Pyo | - |
dc.date.accessioned | 2023-05-08T00:40:48Z | - |
dc.date.available | 2023-05-08T00:40:48Z | - |
dc.date.created | 2018-07-24 | - |
dc.date.created | 2018-07-24 | - |
dc.date.created | 2018-07-24 | - |
dc.date.created | 2018-07-24 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Kidney Research and Clinical Practice, Vol.36 No.4, pp.329-341 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191946 | - |
dc.description.abstract | Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents. Methods: We used a unilateral ureteral obstruction mouse model of kidney fibrosis to determine whether inhibition of sEH activity reduces fibrosis, the final common pathway for chronic kidney disease. Results: sEH activity was inhibited by continuous release of the inhibitor 12-(3-adamantan-1-ylureido)-dodecanoic acid (AUDA) for 1 or 2 weeks. Treatment with AUDA significantly ameliorated tubulointerstitial fibrosis by reducing fibroblast mobilization and enhancing endothelial cell activity. In an in vitro model of endothelial-to-mesenchymal transition (EndMT) using human vascular endothelial cells (HUVECs), AUDA prevented the morphologic changes associated with EndMT and reduced expression of fibroblast-specific protein 1. Furthermore, HUVECs activated by AUDA prevented the epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells in a co-culture system. Conclusion: Our findings suggest that regulation of sEH is a potential target for therapies aimed at delaying the progression of kidney fibrosis by inhibiting EndMT and EMT. | - |
dc.language | 영어 | - |
dc.publisher | 대한신장학회 | - |
dc.title | Active maintenance of endothelial cells prevents kidney fibrosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.23876/j.krcp.2017.36.4.329 | - |
dc.citation.journaltitle | Kidney Research and Clinical Practice | - |
dc.identifier.scopusid | 2-s2.0-85038859683 | - |
dc.citation.endpage | 341 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 329 | - |
dc.citation.volume | 36 | - |
dc.identifier.kciid | ART002291524 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Joo-Youn | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Oh, Yun Kyu | - |
dc.contributor.affiliatedAuthor | Lim, Chun Soo | - |
dc.contributor.affiliatedAuthor | Kim, Yon Su | - |
dc.contributor.affiliatedAuthor | Lee, Jung Pyo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SOLUBLE EPOXIDE HYDROLASE | - |
dc.subject.keywordPlus | TO-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | RENAL FIBROSIS | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | EMERGE | - |
dc.subject.keywordAuthor | Epithelial-mesenchymal transition | - |
dc.subject.keywordAuthor | Endothelial dysfunction | - |
dc.subject.keywordAuthor | Endothelial-to-mesenchymal transition | - |
dc.subject.keywordAuthor | Kidney fibrosis | - |
dc.subject.keywordAuthor | Soluble epoxide hydrolase | - |
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