Publications
Detailed Information
A Comprehensive Comparative Analysis of the Histomorphological Features of ALK-Rearranged Lung Adenocarcinoma Based on Driver Oncogene Mutations: Frequent Expression of Epithelial-Mesenchymal Transition Markers than Other Genotype
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Jang, Se Jin | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Yoo, Seol Bong | - |
dc.contributor.author | Sun, Pingli | - |
dc.contributor.author | Jin, Yan | - |
dc.contributor.author | Nam, Kyung Han | - |
dc.contributor.author | Paik, Jin-Ho | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.date.accessioned | 2023-05-08T00:48:57Z | - |
dc.date.available | 2023-05-08T00:48:57Z | - |
dc.date.created | 2021-06-07 | - |
dc.date.created | 2021-06-07 | - |
dc.date.created | 2021-06-07 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.citation | PLoS ONE, Vol.8 No.10, p. e76999 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192054 | - |
dc.description.abstract | Molecular classification of lung cancer correlates well with histomorphological features. However, specific histomorphological features that differentiate anaplastic lymphoma kinase (ALK)-rearranged tumors from ALK-negative tumors have not been fully evaluated. Eighty ALK-rearranged and 213 ALK-negative (91 epidermal growth factor receptor-mutated; 29 K-ras-mutated; 93 triple-negative) resected lung adenocarcinomas were analyzed for several histomorphological parameters and histological subtype. ALK-rearranged tumors were associated with younger age at presentation, frequent nodal metastasis, and higher stage of disease at diagnosis. ALK-rearranged tumors were more likely to show a solid predominant pattern than ALK-negative tumors (43.8%; 35/80; p>0.001). Unlike ALK-negative tumors, a lepidic predominant pattern was not observed in ALK-rearranged tumors (p>0.001). In multivariate analysis, the most significant morphological features that distinguished ALK-rearranged tumors from ALK-negative tumors were cribriform formation (odds ratio [OR], 3.253; p=0.028), presence of mucin-containing cells (OR, 4.899; p=0.008), close relationship to adjacent bronchioles (OR, 5.361; p= 0.001), presence of psammoma bodies (OR, 4.026; p=0.002), and a solid predominant pattern (OR, 13.685; p=0.023). ALK-rearranged tumors exhibited invasive histomorphological features, aggressive behavior and frequent expression of epithelial-mesenchymal transition markers (loss of E-cadherin and expression of vimentin) compared with other genotype (p=0.015). Spatial proximity between bronchus and ALK-rearranged tumors and frequent solid histologic subtype with p63 expression may cause diagnostic difficulties to differentiate squamous cell carcinoma in the small biopsy, whereas p40 was rarely expressed in ALK-rearranged adenocarcinoma. Knowledge of these features may improve the diagnostic accuracy and lead to a better understanding of the characteristic behavior of ALK-rearranged tumors. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | A Comprehensive Comparative Analysis of the Histomorphological Features of ALK-Rearranged Lung Adenocarcinoma Based on Driver Oncogene Mutations: Frequent Expression of Epithelial-Mesenchymal Transition Markers than Other Genotype | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0076999 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000326037000033 | - |
dc.identifier.scopusid | 2-s2.0-84885996181 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | e76999 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Chung, Doo Hyun | - |
dc.contributor.affiliatedAuthor | Paik, Jin-Ho | - |
dc.contributor.affiliatedAuthor | Chung, Jin-Haeng | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | EGFR MUTATIONS | - |
dc.subject.keywordPlus | GENE REARRANGEMENT | - |
dc.subject.keywordPlus | CLINICAL-FEATURES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | P63 | - |
dc.subject.keywordPlus | DELTA-NP63 | - |
dc.subject.keywordPlus | IMMUNOREACTIVITY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EML4-ALK | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.