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Evaluation of lymph node metastases: Comparison of gadofluorine M-enhanced MRI and diffusion-weighted MRI in a rabbit VX2 rectal cancer model
Cited 5 time in
Web of Science
Cited 7 time in Scopus
- Authors
- Issue Date
- 2012-05
- Publisher
- John Wiley & Sons Inc.
- Citation
- Journal of Magnetic Resonance Imaging, Vol.35 No.5, pp.1179-1186
- Abstract
- Purpose: To compare the diagnostic performance of a diffusion-weighted imaging (DWI) dataset and a gadofluorine M-enhanced imaging dataset for identifying lymph node (LN) metastases in a rabbit rectal cancer model. Materials and Methods: VX2 carcinomas were injected into the rectum of 26 rabbits. Four weeks later, T2weighted imaging (T2WI), pre-T1WI, DWI, and post-T1WI were performed. Two radiologists independently reviewed the DWI set (T2WI, pre-T1WI, DWI) and the gadofluorine M set (T2WI, pre-and post-T1WI) and recorded their confidence scores for LN metastasis on a per-LN basis. Receiver operating characteristic (ROC) analysis was performed to compare the area under the ROC curve (Az) of the two imaging sets. Histopathologic results were used as the reference standard. Results: The Az and sensitivity of the gadofluorine M set were comparable to those of the DWI set (Az, for reader 1, 0.849, 0.829, P 0.571; for reader 2, 0.923, 0.876, P 0.212; sensitivity, for reader 1, 97%, 97%; for reader 2, 97%, 92%, P 0.304). The specificity of the former was greater than that of the latter (for reader 1, 65%, 53%, P 0.0003; for reader 2, 81%, 68%, P 0.01). Conclusion: Gadofluorine M-enhanced images provided greater specificity than DWI for identifying LN metastases, whereas the Az and sensitivity of the former were comparable to those of the latter.
- ISSN
- 1053-1807
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