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Extranodal NK/T Cell Lymphoma Accompanied by Heavy Eosinophilic Infiltration and Peripheral Blood Eosinophilia, Involving Skeletal Muscles

Cited 7 time in Web of Science Cited 0 time in Scopus
Authors

Paik, Jin Ho; Jeon, Yoon Kyung; Go, Heounjeong; Kim, Chul Woo

Issue Date
2011-07
Publisher
Korean Society of Pathologists
Citation
Korean Journal of Pathology, Vol.45, pp.S70-S74
Abstract
The patient was a 52-year-old female with swelling in both lower legs and peripheral blood eosinophilia. Biopsy specimen revealed the heavy infiltration of eosinophils with sparse small lymphocytes showing mild atypia. The diagnosis was Kimura disease. The symptoms including eosinophilia were relieved by steroid treatment. At 17 months from initial biopsy, the patient developed swelling of the buttock. At 25 months, fever and dyspnea with multiple lung nodules developed. Wedge resection revealed multiple aggregates of CD3(+), CD56(+), Epstein-Barr virus(+) large atypical lymphocytes with necrosis. The patient was finally diagnosed with extranodal NK/T cell lymphoma (NKTL). Epstein-Barr virus in situ hybridization retrospectively performed on the previous biopsies demonstrated Epstein-Barr virus infection in small CD3(+) lymphocytes. The patient expired after 26 months despite chemotherapy. Blood eosinophilia correlated well with disease activity during the clinical course. This case shows not only unusual histologic features, which hampered the correct diagnosis, but also a unique clinical manifestation of NKTL.
ISSN
1738-1843
URI
https://hdl.handle.net/10371/192110
DOI
https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S70
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Paik, Jin Ho백진호
(기금)부교수
  • College of Medicine
  • Department of Medicine
Research Area Head and Neck Pathology, Hematopathology, Renal Pathology, 두경부병리학, 신장병리학, 혈액병리학

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