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Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection
Cited 24 time in
Web of Science
Cited 24 time in Scopus
- Authors
- Issue Date
- 2019-08
- Publisher
- Frontiers Media S.A.
- Citation
- Frontiers in Immunology, Vol.10 No.AUG
- Abstract
- Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however; their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-gamma (IFN-gamma)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8(+) T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8(+) T cells. Consequently, impaired memory formation of CD8(+) T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8(+) T cells primed by moDCs was responsible for the enhanced memory programming of CD8(+) T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8(+) T cells during infection and pave the way for the development of a novel therapeutic intervention on infection.
- ISSN
- 1664-3224
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