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Leucine supplementation in maternal high-fat diet alleviated adiposity and glucose intolerance of adult mice offspring fed a postweaning high-fat diet
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Juhae | - |
dc.contributor.author | Kim, Juyoung | - |
dc.contributor.author | Kwon, Young Hye | - |
dc.date.accessioned | 2023-05-12T08:23:02Z | - |
dc.date.available | 2023-05-12T17:29:28Z | - |
dc.date.issued | 2023-04-15 | - |
dc.identifier.citation | Lipids in Health and Disease, 22(1):50 | ko_KR |
dc.identifier.issn | 1476-511X | - |
dc.identifier.uri | https://hdl.handle.net/10371/192399 | - |
dc.description.abstract | Background
Combined maternal and postnatal high-fat (HF) diet intake predisposes offspring to metabolic dysregulation during adulthood. As the inhibitory effects of leucine consumption on obesity and metabolic disorders have been reported, the effects of maternal leucine supplementation on metabolic dysregulation in adult offspring were investigated. Methods Female mice were exposed to a control (C) or HF diet, with or without leucine (L) supplementation (1.5%, w/v), 3weeks before mating, during pregnancy, and during lactation (C, CL, HF, and HFL). Male offspring were exposed to an HF diet for 12weeks after weaning (C/HF, CL/HF, HF/HF, and HFL/HF). Serum biochemical parameters were determined for both the dams and offspring. Oral glucose tolerance test and qRT-PCR analysis were used to investigate metabolic dysregulation in the offspring. Results HFL dams exhibited higher relative adipose tissue weights than HF dams. Body weight, relative adipose tissue weight, and serum glucose levels were lower in the HFL/HF offspring than in the HF/HF offspring. Maternal leucine supplementation tended to alleviate glucose intolerance in the offspring of HF diet-fed dams. Additionally, mRNA levels of fibroblast growth factor 21 (FGF21), a hepatokine associated with glucose homeostasis, were higher in HFL/HF offspring than in HF/HF offspring and were negatively correlated with adiposity and serum glucose levels. ThemRNA levels of genes encoding a FGF21 receptor complex, Fgf receptor 1 and klotho β, and its downstream targets, proliferator‐activated receptor‐γ co‐activator 1α and sirtuin 1, were higher in adipose tissues of the HFL/HF offspring than in those of the HF/HF offspring. Serum lipid peroxide levels were lower in HFL dams than in HF dams and positively correlated with body and adipose tissue weights of offspring. Conclusions Leucine supplementation in HF diet-fed dams, but not in control diet-fed dams, resulted in an anti-obesity phenotype accompanied by glucose homeostasis in male offspring challenged with postnatal HF feeding. Activation of FGF21 signaling in the adipose tissue of offspring may be responsible for these beneficial effects of leucine. | ko_KR |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea grant funded by the Ministry of Science, ICT and Future Planning (No. 2014R1A1A3052400). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Adiposity | - |
dc.subject | FGF21 | - |
dc.subject | High-fat diet | - |
dc.subject | Glucose homeostasis | - |
dc.subject | Leucine | - |
dc.subject | Maternal diet | - |
dc.subject | Mouse offspring | - |
dc.subject | Oxidative stress | - |
dc.title | Leucine supplementation in maternal high-fat diet alleviated adiposity and glucose intolerance of adult mice offspring fed a postweaning high-fat diet | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12944-023-01812-4 | ko_KR |
dc.citation.journaltitle | Lipids in Health and Disease | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2023-04-16T03:27:10Z | - |
dc.citation.number | 50 | ko_KR |
dc.citation.volume | 22 | ko_KR |
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