Publications
Detailed Information
Ceria Nanoparticles as Copper Chaperones that Activate SOD1 for Synergistic Antioxidant Therapy to Treat Ischemic Vascular Diseases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, Gwang-Bum | - |
dc.contributor.author | Kim, Young Geon | - |
dc.contributor.author | Yoo, Tae Yong | - |
dc.contributor.author | Kim, Yeong Hwan | - |
dc.contributor.author | Kim, Kang | - |
dc.contributor.author | Hyun, Jiyu | - |
dc.contributor.author | Soh, Min | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Bhang, Suk Ho | - |
dc.date.accessioned | 2023-05-17T08:58:19Z | - |
dc.date.available | 2023-05-17T08:58:19Z | - |
dc.date.created | 2023-05-11 | - |
dc.date.created | 2023-05-11 | - |
dc.date.created | 2023-05-11 | - |
dc.date.created | 2023-05-11 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.citation | Advanced Materials, Vol.35 No.16, p. 2208989 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192435 | - |
dc.description.abstract | All exogenous nanomaterials undergo rapid biotransformation once injected into the body and fall short of executing the intended purpose. Here, it is reported that copper-deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects over pristine ceria nanoparticles, as the released copper buffers the depletion of glutathione while providing the bioavailable copper as a cofactor for the antioxidant enzyme, superoxide dismutase 1. The upregulated intracellular antioxidants along with the ceria nanoparticles synergistically scavenge reactive oxygen species and promote anti-inflammation and M2 polarization of macrophages by modulating signal transducer and activator of transcription 1 and 6 (STAT1 and STAT6). The therapeutic effect of CuCe NPs is demonstrated in ischemic vascular diseases (i.e., murine models of hindlimb ischemia and myocardial infarction) in which the copper-deposition affords increased perfusion and alleviation in tissue damage. The results provide rationale that metal oxide nanomaterials can be designed in a way to induce the upregulation of specific biological factors for optimal therapeutic performance. | - |
dc.language | 영어 | - |
dc.publisher | WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.title | Ceria Nanoparticles as Copper Chaperones that Activate SOD1 for Synergistic Antioxidant Therapy to Treat Ischemic Vascular Diseases | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adma.202208989 | - |
dc.citation.journaltitle | Advanced Materials | - |
dc.identifier.wosid | 000946992200001 | - |
dc.identifier.scopusid | 2-s2.0-85150642333 | - |
dc.citation.number | 16 | - |
dc.citation.startpage | 2208989 | - |
dc.citation.volume | 35 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | antioxidants | - |
dc.subject.keywordAuthor | nanozymes | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | superoxide dismutase 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.