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New azaspiracids in Amphidomataceae (Dinophyceae)

Cited 89 time in Web of Science Cited 101 time in Scopus

Krock, Bernd; Tillmann, Urban; Voss, Daniela; Koch, Boris P.; Salas, Rafael; Witt, Matthias; Potvin, Eric; Jeong, Hae Jin

Issue Date
Pergamon Press
Toxicon, Vol.60 No.5, pp.830-839
Azaspiracids (AZAs) are a group of lipophilic polyether toxins implicated in incidents of shellfish poisoning in humans, particularly in northern Europe, which are produced by the small marine dinoflagellate Azadinium spinosum. Other related species/strains of the Amphidomataceae have not been proven to date to contain any of the known azaspiracids. Closer analyses of these species/strains by triple quadrupole mass spectrometry in the precursor and product ion mode now revealed four new compounds with high similarity to azaspiracids, all of them with a characteristic rn/z 348 fragment but with absence of the m/z 362 fragment. These compounds were detected in three species/strains, i.e. in North Sea isolates of Azadinium poporum (molecular mass: 845.5 Da), in a Korean isolate which has been designated as A. cf. poporum (molecular mass: 857.5 Da) and in Amphidoma languida isolated from Bantry Bay, Ireland (molecular masses: 815.5 and 829.5 Da). Cell quotas of roughly 2-20 fg per cell were in the same range as found for AZA-1/-2 in A. spinosum. Structures for all compounds were proposed by interpretation of fragmentation patterns and high resolution mass measurements using Fourier transform ion cyclotron resonance-mass spectrometry (FTICR-MS). (C) 2012 Elsevier Ltd. All rights reserved.
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  • College of Natural Sciences
  • Department of Earth and Environmental Sciences
Research Area Aquatic Microbial Ecology, Biological Oceanography, Plankton


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