Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice

Abstract

Increased fat intake is known to be a major cause of prostate cancer. In this study, we investigated theeffect of dietary high fat on prostate intraepithelial neoplasia using transgenic adenocarcinoma mouseprostate (TRAMP) mice. Six-week-old male TRAMP mice were fed AIN93G (control group, 4.0 kcal/kg,n=6) and AIN93G-HFD (experimental group, 4.8 kcal/kg, n=7) for 10 weeks. Prostate histopathology,urogenital tract (UGT) weight, epididymal white adipose tissue weight, argyrophilic nucleolar organizerregions (AgNORs) counts, and serum leptin levels were examined. AIN93G-HFD fed group showedprogressed neoplastic lesions in the prostate (P<0.05) compared to AIN93G fed group. AIN93G-HFDintake resulted in a increase in the weight of UGT (P<0.05) and epididymal white adipose tissue. Thenumber of Ag-NOR positive dots significantly increased in each prostate lobe and final serum leptinlevels in AIN93G-HFD fed group were about twice those of AIN93G fed group (P<0.05). Dietary high fatwas related to the prostate cancer progression in the early stage of TRAMP mice and increased serumleptin levels, suggesting that the regulation of dietary components could delay the progression of prostatecancer.