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Protective effects of vitamin E against 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos
DC Field | Value | Language |
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dc.contributor.author | Na, Yi-Rang | - |
dc.contributor.author | Seok, Seung-Hyeok | - |
dc.contributor.author | Baek, Min-Won | - |
dc.contributor.author | Lee, Hui-Young | - |
dc.contributor.author | Kim, Dong-Jae | - |
dc.contributor.author | Park, Sung-Hoon | - |
dc.contributor.author | Lee, Hyun-Kyoung | - |
dc.contributor.author | Park, Jae-Hak | - |
dc.date.accessioned | 2023-07-07T08:02:00Z | - |
dc.date.available | 2023-07-07T08:02:00Z | - |
dc.date.created | 2022-05-13 | - |
dc.date.created | 2022-05-13 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | Ecotoxicology and Environmental Safety, Vol.72 No.3, pp.714-719 | - |
dc.identifier.issn | 0147-6513 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194831 | - |
dc.description.abstract | 3.3 ',4,4 ',5-Pentachlorinated biphenyls 126 (PCB126) is a global environmental contaminant that can induce cellular oxidative stress. We investigated whether vitamin E can protect against toxicity from PCB126 during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to 100 nM PCB126 and compared with a second group that was co-exposed with 100 mu M vitamin E until 5 days post fertilization. PCB126 induced pericardial sac edema, yolk sac edema, and growth retardation in zebrafish embyos. In contrast, vitamin E co-exposure group did not show any gross changes. Real-time PCR results showed that vitamin E co-exposure group were restored to control group for the expression levels of heat shock protein 70 Cognate, aryl hydrocarbon receptor type-2, cytochrome P450 1A, and superoxide dismutase-1. These data give insights into the use of vitamin E to reduce PCB126-mediated toxicity and into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of AHR agonists. (c) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Protective effects of vitamin E against 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ecoenv.2008.09.015 | - |
dc.citation.journaltitle | Ecotoxicology and Environmental Safety | - |
dc.identifier.wosid | 000263762100007 | - |
dc.identifier.scopusid | 2-s2.0-59149093807 | - |
dc.citation.endpage | 719 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 714 | - |
dc.citation.volume | 72 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Seok, Seung-Hyeok | - |
dc.contributor.affiliatedAuthor | Park, Jae-Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | CIRCULATION FAILURE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | LINOLEIC-ACID | - |
dc.subject.keywordPlus | DANIO-RERIO | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | - |
dc.subject.keywordAuthor | 3. 3 3 &apos | - |
dc.subject.keywordAuthor | 44 &apos | - |
dc.subject.keywordAuthor | 5-Pentachlorobiphenyl (PCB126) | - |
dc.subject.keywordAuthor | Vitamin E | - |
dc.subject.keywordAuthor | Zebrafish (Dania rerio) embryo | - |
dc.subject.keywordAuthor | CYP1A | - |
dc.subject.keywordAuthor | HSC70 | - |
dc.subject.keywordAuthor | SOD2 | - |
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