Publications

Detailed Information

Protective effects of vitamin E against 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos

DC Field Value Language
dc.contributor.authorNa, Yi-Rang-
dc.contributor.authorSeok, Seung-Hyeok-
dc.contributor.authorBaek, Min-Won-
dc.contributor.authorLee, Hui-Young-
dc.contributor.authorKim, Dong-Jae-
dc.contributor.authorPark, Sung-Hoon-
dc.contributor.authorLee, Hyun-Kyoung-
dc.contributor.authorPark, Jae-Hak-
dc.date.accessioned2023-07-07T08:02:00Z-
dc.date.available2023-07-07T08:02:00Z-
dc.date.created2022-05-13-
dc.date.created2022-05-13-
dc.date.issued2009-03-
dc.identifier.citationEcotoxicology and Environmental Safety, Vol.72 No.3, pp.714-719-
dc.identifier.issn0147-6513-
dc.identifier.urihttps://hdl.handle.net/10371/194831-
dc.description.abstract3.3 ',4,4 ',5-Pentachlorinated biphenyls 126 (PCB126) is a global environmental contaminant that can induce cellular oxidative stress. We investigated whether vitamin E can protect against toxicity from PCB126 during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to 100 nM PCB126 and compared with a second group that was co-exposed with 100 mu M vitamin E until 5 days post fertilization. PCB126 induced pericardial sac edema, yolk sac edema, and growth retardation in zebrafish embyos. In contrast, vitamin E co-exposure group did not show any gross changes. Real-time PCR results showed that vitamin E co-exposure group were restored to control group for the expression levels of heat shock protein 70 Cognate, aryl hydrocarbon receptor type-2, cytochrome P450 1A, and superoxide dismutase-1. These data give insights into the use of vitamin E to reduce PCB126-mediated toxicity and into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of AHR agonists. (c) 2008 Elsevier Inc. All rights reserved.-
dc.language영어-
dc.publisherAcademic Press-
dc.titleProtective effects of vitamin E against 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos-
dc.typeArticle-
dc.identifier.doi10.1016/j.ecoenv.2008.09.015-
dc.citation.journaltitleEcotoxicology and Environmental Safety-
dc.identifier.wosid000263762100007-
dc.identifier.scopusid2-s2.0-59149093807-
dc.citation.endpage719-
dc.citation.number3-
dc.citation.startpage714-
dc.citation.volume72-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorSeok, Seung-Hyeok-
dc.contributor.affiliatedAuthorPark, Jae-Hak-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusINDUCED OXIDATIVE STRESS-
dc.subject.keywordPlusENDOTHELIAL-CELLS-
dc.subject.keywordPlusCIRCULATION FAILURE-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusREACTIVE OXYGEN-
dc.subject.keywordPlusLINOLEIC-ACID-
dc.subject.keywordPlusDANIO-RERIO-
dc.subject.keywordPlusDNA-DAMAGE-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlus2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-
dc.subject.keywordAuthor3. 3 3 &apos-
dc.subject.keywordAuthor44 &apos-
dc.subject.keywordAuthor5-Pentachlorobiphenyl (PCB126)-
dc.subject.keywordAuthorVitamin E-
dc.subject.keywordAuthorZebrafish (Dania rerio) embryo-
dc.subject.keywordAuthorCYP1A-
dc.subject.keywordAuthorHSC70-
dc.subject.keywordAuthorSOD2-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Laboratory Animal Medicine, Toxicologic Pathology

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share