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The anti-inflammatory drug Diclofenac retains anti-listerial activity in vivo
DC Field | Value | Language |
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dc.contributor.author | Dutta, N. K. | - |
dc.contributor.author | Mazumdar, K. | - |
dc.contributor.author | Seok, S. H. | - |
dc.contributor.author | Park, J. H. | - |
dc.date.accessioned | 2023-07-07T08:02:36Z | - |
dc.date.available | 2023-07-07T08:02:36Z | - |
dc.date.created | 2022-05-13 | - |
dc.date.created | 2022-05-13 | - |
dc.date.issued | 2008-01 | - |
dc.identifier.citation | Letters in Applied Microbiology, Vol.47 No.2, pp.106-111 | - |
dc.identifier.issn | 0266-8254 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194844 | - |
dc.description.abstract | Aims: The interactions between nonsteroidal anti-inflammatory drugs (NSAID) and Listeria monocytogenes have not been sufficiently documented to date. The aim of this study was to investigate the possible effects of Diclofenac (Dc) in a murine listerial infection model. Methods and Results: Dc was administered orally at 2.5 mu g g(-1) to female albino strain of laboratory mouse (BALB/c) thrice postinfection (1 x 10(8) CFU ml(-1) oral challenge with L. monocytogenes ATCC 51774), which resulted in significantly (P < 0.01) reduced bacterial counts in liver and spleen, decreased (10-fold, P < 0.05) hepatic colonization and necrosis, and caused up-regulation of the expression of inflammatory cytokines (interferon-gamma, interleukin-1 beta, tumour necrosis factor-alpha), compared with drug-free control. Conclusions: Dc may be useful as a promising adjuvant to the existing therapies in controlling systemic listerial infection. Further, quantitative structure-activity relationship studies might contribute in manipulating it as a lead compound for the synthesis of new, more effective nonantibiotics, perhaps, devoid of side-effects that could be recommended as a compassionate therapy for listeriosis. Significance and Impact of the study: This is the first in vivo study designed to evaluate the antilisterial effect of the NSAID Dc with special emphasis on the immunological mechanism of action of the drug. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | The anti-inflammatory drug Diclofenac retains anti-listerial activity in vivo | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1472-765X.2008.02391.x | - |
dc.citation.journaltitle | Letters in Applied Microbiology | - |
dc.identifier.wosid | 000258220400006 | - |
dc.identifier.scopusid | 2-s2.0-48749115608 | - |
dc.citation.endpage | 111 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 106 | - |
dc.citation.volume | 47 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Seok, S. H. | - |
dc.contributor.affiliatedAuthor | Park, J. H. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MONOCYTOGENES | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | GASTRITIS | - |
dc.subject.keywordPlus | SODIUM | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordAuthor | diclofenac | - |
dc.subject.keywordAuthor | in vivo activity | - |
dc.subject.keywordAuthor | Listeria monocytogenes | - |
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