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Effect of the similarity of gut microbiota composition between donor and recipient on graft function after living donor kidney transplantation

Cited 9 time in Web of Science Cited 10 time in Scopus
Authors

Kim, Ji Eun; Kim, Hyo-Eun; Cho, Hyunjeong; Park, Ji In; Kwak, Min-Jung; Kim, Byung-Yong; Yang, Seung Hee; Lee, Jung Pyo; Kim, Dong Ki; Joo, Kwon Wook; Kim, Yon Su; Kim, Bong-Soo; Lee, Hajeong

Issue Date
2020-11-03
Publisher
Nature Publishing Group
Citation
Scientific Reports, Vol.10 No.1, p. 18881
Abstract
Graft outcomes of unrelated donor kidney transplant are comparable with those of related donor kidney transplant despite their genetic distance. This study aimed to identify whether the similarity of donor-recipient gut microbiota composition affects early transplant outcomes. Stool samples from 67 pairs of kidney transplant recipients and donors were collected. Gut microbiota differences between donors and recipients were determined using weighted UniFrac distance. Among the donor-recipient pairs, 30 (44.8%) pairs were related, while 37 (55.2%) were unrelated. The unrelated pairs, especially spousal pairs, had similar microbial composition, and they more frequently shared their meals than related pairs did. The weighted UniFrac distance showed an inverse correlation with the 6-month allograft function (p = 0.034); the correlation was significant in the unrelated pairs (p = 0.003). In the unrelated pairs, the microbial distance showed an excellent accuracy in predicting the estimated glomerular filtration rate of < 60 mL/min/1.73 m(2) at 6-months post-transplantation and was better than human leukocyte antigen incompatibility and rejection. The incidence of infection within 6 months post-transplantation increased in the recipients having dissimilar microbiota with donors compared to the other recipients. Thus, pre-transplantation microbial similarity in unrelated donors and recipients may be associated with 6-month allograft function.
ISSN
2045-2322
URI
https://hdl.handle.net/10371/194994
DOI
https://doi.org/10.1038/s41598-020-76072-8
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  • College of Medicine
  • Department of Medicine
Research Area Nephrology, Transplantation, Urology

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