Publications
Detailed Information
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Cited 431 time in
Web of Science
Cited 458 time in Scopus
- Authors
- Issue Date
- 2019-09
- Publisher
- Nature Publishing Group
- Citation
- Nature Reviews Gastroenterology and Hepatology, Vol.16 No.9, pp.531-543
- Abstract
- Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate between innocuous antigens and potential pathogens to maintain oral tolerance. However, in individuals with a genetic and environmental predisposition, regulation of intestinal immunity is impaired, leading to chronic relapsing immune activation and pathologies of the gastrointestinal tract, such as IBD. As evidence suggests a causal link between defects in the resolution of intestinal inflammation and altered monocyte-macrophage differentiation in patients with IBD, macrophages have been considered as a novel potential target to develop new treatment approaches. This Review discusses the molecular and cellular mechanisms involved in the differentiation and function of intestinal macrophages in homeostasis and inflammation, and their role in resolving the inflammatory process. Understanding the molecular pathways involved in the specification of intestinal macrophages might lead to a new class of targets that promote remission in patients with IBD.
- ISSN
- 1759-5045
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.