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Transcriptomic Profiling and Cellular Composition of Creeping Fat in Crohn's disease

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dc.contributor.authorKim, Kyuwon-
dc.contributor.authorPark, Sojung-
dc.contributor.authorLee, Yoonho-
dc.contributor.authorBaek, Jiwon-
dc.contributor.authorKim, Yongjae-
dc.contributor.authorHwang, Sung Wook-
dc.contributor.authorLee, Jong Lyul-
dc.contributor.authorPark, Sang Hyoung-
dc.contributor.authorYang, Suk-Kyun-
dc.contributor.authorHan, Buhm-
dc.contributor.authorSong, Kyuyoung-
dc.contributor.authorYoon, Yong Sik-
dc.contributor.authorLee, Ho-Su-
dc.contributor.authorYe, Byong Duk-
dc.date.accessioned2023-10-30T01:43:37Z-
dc.date.available2023-10-30T01:43:37Z-
dc.date.created2023-10-24-
dc.date.created2023-10-24-
dc.date.created2023-10-24-
dc.date.created2023-10-24-
dc.date.issued2024-02-
dc.identifier.citationJournal of Crohn's and Colitis, Vol.18 No.2, pp.223-232-
dc.identifier.issn1873-9946-
dc.identifier.urihttps://hdl.handle.net/10371/195814-
dc.description.abstractBackground and Aims: Creeping fat [CF] is a poorly understood feature of Crohn's disease [CD], characterized by the wrapping of mesenteric adipose tissue [MAT] around the inflamed intestine. The aim of this study was to investigate the transcriptional profile and compositional features of CF. Methods: We collected 59 MAT samples: 23 paired samples from patients with CD (CF [CD-CF] and MAT around the uninflamed intestine [CD-MAT]) and 13 MAT samples from non-CD patients [Con-MAT]. Differentially expressed gene [DEG], functional pathway, cell deconvolution, and gene co-expression network analyses were performed. Results: By comparing three different MAT samples, we identified a total of 529 DEGs [|log(2)FoldChange| > 1.5; false discovery rate < 0.05]. Of these, 323 genes showed an incremental pattern from Con-MAT to CD-MAT, and to CD-CF, while 105 genes displayed a decremental pattern. Genes with an incremental pattern were related to immune cell responses, including B- andT-cell activation, while genes with a decremental pattern were involved in cell trafficking and migration. Cell deconvolution analysis revealed significant changes in cellular composition between the CD-CF and Con-MAT groups, with increased proportions of B-cells/plasma cells [p = 1.16 x 10(-4)], T-cells [p = 3.66 x 10(-3)], and mononuclear phagocytes [p = 3.53 x 10(-2)] in the CD-CF group. In contrast, only the B-cell/plasma cell component showed a significant increase [p = 1.62 x 10(-2)] in the CD-MAT group compared to Con-MAT. Conclusion: The distinct transcriptional profiles and altered cellular components of each MAT found in our study provide insight into the mechanisms behind CF and highlight its possible role in the pathogenesis of CD.-
dc.language영어-
dc.publisherElsevier Science-
dc.titleTranscriptomic Profiling and Cellular Composition of Creeping Fat in Crohn's disease-
dc.typeArticle-
dc.identifier.doi10.1093/ecco-jcc/jjad141-
dc.citation.journaltitleJournal of Crohn's and Colitis-
dc.identifier.wosid001070320600001-
dc.identifier.scopusid2-s2.0-85186254148-
dc.citation.endpage232-
dc.citation.number2-
dc.citation.startpage223-
dc.citation.volume18-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHan, Buhm-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSET ENRICHMENT ANALYSIS-
dc.subject.keywordPlusWHITE ADIPOSE-TISSUE-
dc.subject.keywordPlusMESENTERIC FAT-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusHALLMARK-
dc.subject.keywordPlusGENES-
dc.subject.keywordAuthorCrohn&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorcreeping fat-
dc.subject.keywordAuthormesenteric adipose tissue-
dc.subject.keywordAuthortranscriptomic analysis-
dc.subject.keywordAuthordifferential gene expression-
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  • College of Medicine
  • Department of Medicine
Research Area Bioinformatics, Genomics, Statistical Genetics

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