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Tracking antigen-specific TCR clonotypes in SARS-CoV-2 infection reveals distinct severity trajectories
DC Field | Value | Language |
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dc.contributor.author | Kim, Ik Soo | - |
dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Lee, Seung Jae | - |
dc.contributor.author | Lee, Chang-Han | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Seo, Chaehwa | - |
dc.contributor.author | Kim, Gwanghun | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Park, Kyoung Sun | - |
dc.contributor.author | Chang, Euijin | - |
dc.contributor.author | Jung, Jongtak | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Lee, Jong-Eun | - |
dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.date.accessioned | 2024-04-26T00:56:49Z | - |
dc.date.available | 2024-04-26T00:56:49Z | - |
dc.date.created | 2023-11-15 | - |
dc.date.created | 2023-11-15 | - |
dc.date.issued | 2023-11 | - |
dc.identifier.citation | Journal of Medical Virology, Vol.95 No.11, p. e29199 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199560 | - |
dc.description.abstract | Despite the importance of antigen-specific T cells in infectious disease, characterizing and tracking clonally amplified T cells during the progression of a patient's symptoms remain unclear. Here, we performed a longitudinal, in-depth single-cell multiomics analysis of samples from asymptomatic, mild, usual severe, and delayed severe patients of SARS-CoV-2 infection. Our in-depth analysis revealed that hyperactive or improper T-cell responses were more aggressive in delayed severe patients. Interestingly, tracking of antigen-specific T-cell receptor (TCR) clonotypes along the developmental trajectory indicated an attenuation in functional T cells upon severity. In addition, increased glycolysis and interleukin-6 signaling in the cytotoxic T cells were markedly distinct in delayed severe patients compared to usual severe patients, particularly in the middle and late stages of infection. Tracking B-cell receptor clonotypes also revealed distinct transitions and somatic hypermutations within B cells across different levels of disease severity. Our results suggest that single-cell TCR clonotype tracking can distinguish the severity of patients through immunological hallmarks, leading to a better understanding of the severity differences in and improving the management of infectious diseases by analyzing the dynamics of immune responses over time. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Tracking antigen-specific TCR clonotypes in SARS-CoV-2 infection reveals distinct severity trajectories | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jmv.29199 | - |
dc.citation.journaltitle | Journal of Medical Virology | - |
dc.identifier.wosid | 001124416600006 | - |
dc.identifier.scopusid | 2-s2.0-85175770415 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | e29199 | - |
dc.citation.volume | 95 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Ik Soo | - |
dc.contributor.affiliatedAuthor | Lee, Chang-Han | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Hong Bin | - |
dc.contributor.affiliatedAuthor | Kim, Nam Joong | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.contributor.affiliatedAuthor | Shin, Hyun Mu | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | MULTI-OMICS | - |
dc.subject.keywordPlus | CYTOKINE STORM | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordAuthor | BCR tracking | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | single-cell multiomics | - |
dc.subject.keywordAuthor | TCR tracking | - |
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