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Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Cited 10 time in Web of Science Cited 10 time in Scopus

Kang, Chang Kyung; Shin, Hyun Mu; Choe, Pyoeng Gyun; Park, Jiyoung; Hong, Jisu; Seo, Jung Seon; Lee, Yung Hie; Chang, Euijin; Kim, Nam Joong; Kim, Minji; Kim, Yong-Woo; Kim, Hang-Rae; Lee, Chang-Han; Seo, Jun-Young; Park, Wan Beom; Oh, Myoung-Don

Issue Date
BioMed Central
BMC Medicine, Vol.20 No.1, p. 181
Background Practical guidance is needed regarding the vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals in resource-limited countries. It includes the number of vaccine doses that should be given to unvaccinated patients who experienced COVID-19 early in the pandemic. Methods We recruited COVID-19 convalescent individuals who received one or two doses of an mRNA vaccine within 6 or around 18 months after a diagnosis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Their samples were assessed for IgG-binding or neutralizing activity and cell-mediated immune responses against SARS-CoV-2 wild-type and variants of concern. Results A total of 43 COVID-19 convalescent individuals were analyzed in the present study. The results showed that humoral and cellular immune responses against SARS-CoV-2 wild-type and variants of concern, including the Omicron variant, were comparable among patients vaccinated within 6 versus around 18 months. A second dose of vaccine did not significantly increase immune responses. Conclusion One dose of mRNA vaccine should be considered sufficient to elicit a broad immune response even around 18 months after a COVID-19 diagnosis.
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  • College of Medicine
Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism


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