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Distinct Immune Response at 1 Year Post-COVID-19 According to Disease Severity

Cited 12 time in Web of Science Cited 11 time in Scopus

Kang, Chang Kyung; Kim, Minji; Hong, Jisu; Kim, Gwanghun; Lee, Soojin; Chang, Euijin; Choe, Pyoeng Gyun; Kim, Nam Joong; Kim, Ik Soo; Seo, Jun-Young; Shin, Hyun Mu; Song, Daesub; Lee, Dong-Sup; Kim, Yong-Woo; Lee, Chang-Han; Park, Wan BeomKim, Hang-Rae; Oh, Myoung Don

Issue Date
Frontiers Media S.A.
Frontiers in Immunology, Vol.13, p. 830433
BackgroundDespite the fact of ongoing worldwide vaccination programs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), understanding longevity, breadth, and type of immune response to coronavirus disease-19 (COVID-19) is still important to optimize the vaccination strategy and estimate the risk of reinfection. Therefore, we performed thorough immunological assessments 1 year post-COVID-19 with different severity. MethodsWe analyzed peripheral blood mononuclear cells and plasma samples at 1 year post-COVID-19 in patients who experienced asymptomatic, mild, and severe illness to assess titers of various isotypes of antibodies (Abs) against SARS-CoV-2 antigens, phagocytic capability, and memory B- and T-cell responses. FindingsA total of 24 patients (7, 9, and 8 asymptomatic, mild, and severe patients, respectively) and eight healthy volunteers were included in this study. We firstly showed that disease severity is correlated with parameters of immune responses at 1 year post-COVID-19 that play an important role in protecting against reinfection with SARS-CoV-2, namely, the phagocytic capacity of Abs and memory B-cell responses. InterpretationVarious immune responses at 1 year post-COVID-19, particularly the phagocytic capacity and memory B-cell responses, were dependent on the severity of the prior COVID-19. Our data could provide a clue for a tailored vaccination strategy after natural infection according to the severity of COVID-19.
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  • College of Medicine
  • Department of Medicine
Research Area Immunology, Infectious Diseases, Vaccination, 감염병, 바이러스질환, 예방접종


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