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Longevity of seropositivity and neutralizing antibodies in recovered MERS patients: a 5-year follow-up study

Cited 7 time in Web of Science Cited 7 time in Scopus

Cheon, Shinhye; Park, Uni; Park, Hyoree; Kim, Yuri; Yen Thi Hai Nguyen; Aigerim, Abdimadiyeva; Rhee, Ji-Young; Choi, Jae-Phil; Park, Wan Beom; Park, Sang Won; Kim, Yeonjae; Lim, Dong-Gyun; Yang, Jeong-Sun; Lee, Joo-Yeon; Kim, Yeon-Sook; Cho, Nam-Hyuk

Issue Date
Elsevier Limited
Clinical Microbiology and Infection, Vol.28 No.2, pp.292-296
Objectives: We aimed to assess the longevity of spike-specific antibody responses and neutralizing activity in the plasma of recovered Middle East respiratory syndrome (MERS) patients. Methods: We traced the antibody responses and neutralizing activity against MERS coronavirus (MERSCoV) in peripheral blood samples collected from 70 recovered MERS patients for 5 years after the 2015 MERS outbreak in South Korea. We also measured the half-life of neutralizing antibody titres in the longitudinal specimens. Results: The seropositivity rate persisted for up to 4 years (50.7-56.1%), especially in MERS patients who suffered from severe pneumonia, and then decreased (35.9%) in the fifth year. Although the spike-specific antibody responses decreased gradually, the neutralizing antibody titres decreased more rapidly (halflife: 20 months) in 19 participants without showing negative seroconversion during the study period. Only five (26.3%) participants had neutralizing antibody titres greater than 1/1000 of PRNT50, and a high neutralizing antibody titre over 1/5000 was not detected in the participants at five years after infection. Discussion: The seropositivity rate of the recovered MERS patients persisted up to 4 years after infection and significantly dropped in the fifth year, whereas the neutralizing antibody titres against MERS-CoV decreased more rapidly and were significantly reduced at 4 years after infection. Shinhye Cheon, Clin Microbiol Infect 2022;28:292
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  • College of Medicine
  • Department of Medicine
Research Area Immunology, Infectious Diseases, Vaccination, 감염병, 바이러스질환, 예방접종


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