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Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus
Cited 9 time in
Web of Science
Cited 10 time in Scopus
- Authors
- Issue Date
- 2016-11
- Publisher
- American Society for Microbiology
- Citation
- Antimicrobial Agents and Chemotherapy, Vol.60 No.11, pp.6928-6932
- Abstract
- Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 mu/ml for the Ser-Cys group and 40.32 mu/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.
- ISSN
- 0066-4804
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