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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Cited 187 time in Web of Science Cited 195 time in Scopus

Lee, Giljae; You, Hyun Ju; Bajaj, Jasmohan S.; Joo, Sae Kyung; Yu, Junsun; Park, Seoyeon; Kang, Hyena; Park, Jeong Hwan; Kim, Jung Ho; Lee, Dong Hyeon; Lee, Seonhwa; Kim, Won; Ko, GwangPyo

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Nature Publishing Group
Nature Communications, Vol.11 No.1, p. 4982
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or fibrosis severity. Significant alterations in microbiome diversity are observed according to fibrosis severity in non-obese, but not obese, subjects. Ruminococcaceae and Veillonellaceae are the main microbiota associated with fibrosis severity in non-obese subjects. Furthermore, stool bile acids and propionate are elevated, especially in non-obese subjects with significant fibrosis. Fibrosis-related Ruminococcaceae and Veillonellaceae species undergo metagenome sequencing, and four representative species are administered in three mouse NAFLD models to evaluate their effects on liver damage. This study provides the evidence for the role of the microbiome in the liver fibrosis pathogenesis, especially in non-obese subjects.
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  • College of Human Ecology
  • Department of Food and Nutrition
Research Area Biochemistry & Molecular Biology, Food Science & Technology, Microbiology, 미생물학, 분자생물학, 식품공학


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