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Co-culture with bifidobacterium catenulatum improves the growth, gut colonization, and butyrate production of faecalibacterium prausnitzii: In vitro and in vivo studies
DC Field | Value | Language |
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dc.contributor.author | Kim, Heejung | - |
dc.contributor.author | Jeong, Yunju | - |
dc.contributor.author | Kang, Sini | - |
dc.contributor.author | You, Hyun Ju | - |
dc.contributor.author | Ji, Geun Eog | - |
dc.date.accessioned | 2024-05-01T01:30:26Z | - |
dc.date.available | 2024-05-01T01:30:26Z | - |
dc.date.created | 2020-07-13 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Microorganisms, Vol.8 No.5, p. 788 | - |
dc.identifier.issn | 2076-2607 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200091 | - |
dc.description.abstract | Faecalibacterium prausnitzii is a major commensal bacterium in the human gut. It produces short-chain fatty acids that promote intestinal health. However, the bacterium is extremely oxygen-sensitive, making it difficult to develop as a probiotic. To facilitate practical application of F. prausnitzii, we investigated factors that affect its growth and mammalian gut colonization. We evaluated cross-feeding interactions between F. prausnitzii and seven Bifidobacterium strains, and the anti-inflammatory properties of bacterial metabolites produced in co-culture, in vitro and in vivo. Co-culture of F. prausnitzii and Bifidobacterium catenulatum, with fructooligosaccharides as an energy source, resulted in the greatest viable cell-count and butyrate production increases. Further, the co-culture supernatant reduced the amount of proinflammatory cytokines produced by HT-29 cells and RAW 264.7 macrophages, an effect that was similar to that of butyrate. Furthermore, feeding mice both Faecalibacterium and Bifidobacterium enhanced F. prausnitzii gut colonization. Finally, feeding the co-culture supernatant decreased interleukin 8 levels in the colon and increased butyrate levels in the cecum in the dextran sodium sulfate-induced colitis mouse model. These observations indicate that the Faecalibacterium-Bifidobacterium co-culture exerts an anti-inflammatory effect by promoting F. prausnitzii survival and short-chain fatty acid production, with possible implications for the treatment of inflammatory bowel disease. | - |
dc.language | 영어 | - |
dc.publisher | MDPI AG | - |
dc.title | Co-culture with bifidobacterium catenulatum improves the growth, gut colonization, and butyrate production of faecalibacterium prausnitzii: In vitro and in vivo studies | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/microorganisms8050788 | - |
dc.citation.journaltitle | Microorganisms | - |
dc.identifier.wosid | 000540222300169 | - |
dc.identifier.scopusid | 2-s2.0-85085579819 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 788 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | You, Hyun Ju | - |
dc.contributor.affiliatedAuthor | Ji, Geun Eog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | INDUCED COLITIS | - |
dc.subject.keywordPlus | FERMENTATION | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | ACETATE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Faecalibacterium prausnitzii | - |
dc.subject.keywordAuthor | Bifidobacterium catenulatum | - |
dc.subject.keywordAuthor | cross-feeding | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | butyrate | - |
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