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Enhancement of the Tyrosinase Inhibitory Activity of Mori Cortex Radicis Extract by Biotransformation Using Leuconostoc paramesenteroides PR
Cited 10 time in
Web of Science
Cited 11 time in Scopus
- Authors
- Issue Date
- 2012-08
- Citation
- Bioscience, Biotechnology and Biochemistry, Vol.76 No.8, pp.1425-1430
- Abstract
- Mori Cortex Radicis (MCR), the root bark of Morus alba L., consists of various phytochemicals and exhibits a strong inhibitory effect on tyrosinase. To enhance the tyrosinase inhibitory activity of MCR extract without further purification of bioactive compounds, whole MCR extract was biotransformed with crude enzyme extract from a selected lactic acid bacterium, Leuconostoc paramesenteroides PR (LP). Mulberroside A (MA), a major stilbene glucoside of MCR, contains two beta-glucosyl residues at the C3 and C4' positions of oxyresveratrol (OXY). The crude enzyme of LP hydrolyzed the two glycosidic bonds of MA effectively, and 97.1% of MA was biotransformed into OXY within 2 h. Commercial almond beta-glucosidase hydrolyzed only one site of the two glycosidic bonds of MA, and 68.7% of MA was biotransformed to OXY-glucoside. The tyrosinase inhibitory activity of the crude extract of MCR was increased approximately 6.5-fold by biotransformation using LP, and the IC50 value of the transformed MCR was 3.7 mu g/mL.
- ISSN
- 0916-8451
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