Publications
Detailed Information
Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-α-induced monocyte-endothelial trafficking : Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-alpha-induced monocyte-endothelial trafficking
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun-Sook | - |
dc.contributor.author | Choi, Jung-Suk | - |
dc.contributor.author | Kim, Min Soo | - |
dc.contributor.author | You, Hyun Ju | - |
dc.contributor.author | Ji, Geun Eog | - |
dc.contributor.author | Kang, Young-Hee | - |
dc.date.accessioned | 2024-05-01T01:36:45Z | - |
dc.date.available | 2024-05-01T01:36:45Z | - |
dc.date.created | 2021-10-21 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | Chemico-Biological Interactions, Vol.194 No.1, pp.13-22 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200205 | - |
dc.description.abstract | Human leukocyte endothelial adhesion and transmigration occur in the early stage of the pathogenesis of atherosclerosis. Vascular endothelial cells are targeted by pro-inflammatory cytokines modulating many gene proteins responsible for cell adhesion, thrombosis and inflammatory responses. This study examined the potential of compound K to inhibit the pro-inflammatory cytokine TNF-alpha, induction of monocyte adhesion onto TNF-alpha-activated human umbilical vein endothelial cells (HUVEC). HUVEC were cultured with 10 ng/ml TNF-alpha with individual ginsenosides of Rb1, Rc, Re, Rhl and compound K (CK). Ginsenosides at doses of <= 50 mu M did not show any cytotoxicity. TNF-alpha induced THP-1 monocyte adhesion to HUVEC, and such induction was attenuated by Rh1 and CK. Consistently, CK suppressed TNF-alpha-induced expression of HUVEC adhesion molecules of VCAM-1, ICAM-1 and E-selectin, and also Rhl showed a substantial inhibition. Rh1 and CK dampened induction of counter-receptors, alpha 4/beta 1 integrin VLA-4 and alpha L/beta 2 integrin LFA-1 in TNF-alpha-treated THP-1 cells. Additionally, CK diminished THP-1 secretion of MMP-9 required during transmigration, inhibiting transendothelial migration of THP-1 cells. CK blunted TNF-alpha-promoted IL-8 secretion of HUVEC and CXCR1 expression of THP-1 monocytes. Furthermore, INF-alpha-activated endothelial I kappa B phosphorylation and NF-kappa B nuclear translocation were disturbed by CK, and TNF-alpha induction of alpha 4/beta 1 integrin was abrogated by the NF-kappa B inhibitor SN50. These results demonstrate that CK exerts anti-atherogenic activity with blocking leukocyte endothelial interaction and transmigration through negatively mediating NF-kappa B signaling. (C) 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-α-induced monocyte-endothelial trafficking | - |
dc.title.alternative | Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-alpha-induced monocyte-endothelial trafficking | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cbi.2011.08.008 | - |
dc.citation.journaltitle | Chemico-Biological Interactions | - |
dc.identifier.wosid | 000296994800002 | - |
dc.identifier.scopusid | 2-s2.0-80052835896 | - |
dc.citation.endpage | 22 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 13 | - |
dc.citation.volume | 194 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | You, Hyun Ju | - |
dc.contributor.affiliatedAuthor | Ji, Geun Eog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL MIGRATION | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | RH1 | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | TRANSMIGRATION | - |
dc.subject.keywordAuthor | Adhesion molecules | - |
dc.subject.keywordAuthor | Compound K | - |
dc.subject.keywordAuthor | Ginsenoside | - |
dc.subject.keywordAuthor | Integrin | - |
dc.subject.keywordAuthor | Transendothelial migration | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.