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Transformation of Rutin to Antiproliferative Quercetin-3-glucoside by Aspergillus niger

DC Field Value Language
dc.contributor.authorYou, Hyun Ju-
dc.contributor.authorAhn, Hyung Jin-
dc.contributor.authorJi, Geun Eog-
dc.date.accessioned2024-05-01T01:37:12Z-
dc.date.available2024-05-01T01:37:12Z-
dc.date.created2021-12-10-
dc.date.issued2010-10-
dc.identifier.citationJournal of Agricultural and Food Chemistry, Vol.58 No.20, pp.10886-10892-
dc.identifier.issn0021-8561-
dc.identifier.urihttps://hdl.handle.net/10371/200213-
dc.description.abstractThe flavonol quercetin in plants and foods occurs predominantly in the form of glycoside whose sugar moiety affects the bioavailability and the mechanism of its biological activities. The antiproliferative activities of quercetin derivatives such as quercetin aglycone, quercetin-3-beta-D-glucoside (Q3G), and rutin were compared using six different cancer cell lines including colon, breast, hepatocellular, and lung cancer. The IC(50) value of Q3G ranged between 15 and 25 mu M in HT-29, HOT 116, MCF-7, HepG2, and A549 cells. In these five cell lines, Q3G showed the most potent growth inhibition, whereas rutin showed the least potency. Transformation of rutin to Q3G was conducted by controlling alpha-L-rhamnosidase and beta-D-glucosidase activities from crude enzyme extract of Aspergillus niger. Carbon sources during culture and transformation conditions such as pH, temperature, and heat-stability were optimized. After 4 h biotransformation, 99% of rutin was transformed to Q3G and no quercetin was detected. This study presented an efficient biotransformation for the conversion of rutin to Q3G which was newly shown to have more potent antiproliferative effect than quercetin and rutin.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleTransformation of Rutin to Antiproliferative Quercetin-3-glucoside by Aspergillus niger-
dc.typeArticle-
dc.identifier.doi10.1021/jf102871g-
dc.citation.journaltitleJournal of Agricultural and Food Chemistry-
dc.identifier.wosid000283100800014-
dc.identifier.scopusid2-s2.0-78049275937-
dc.citation.endpage10892-
dc.citation.number20-
dc.citation.startpage10886-
dc.citation.volume58-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorYou, Hyun Ju-
dc.contributor.affiliatedAuthorJi, Geun Eog-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusALPHA-L-RHAMNOSIDASES-
dc.subject.keywordPlusLACTOBACILLUS-PLANTARUM-
dc.subject.keywordPlusENZYMATIC MODIFICATION-
dc.subject.keywordPlusFLAVONOID QUERCETIN-
dc.subject.keywordPlusDIETARY FLAVONOIDS-
dc.subject.keywordPlusMAJOR DETERMINANT-
dc.subject.keywordPlusSUGAR MOIETY-
dc.subject.keywordPlusBIOAVAILABILITY-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusGLYCOSIDES-
dc.subject.keywordAuthorQuercetin-3-beta-D-glucoside-
dc.subject.keywordAuthorbiotransformation-
dc.subject.keywordAuthorantiproliferation-
dc.subject.keywordAuthorcancer-
dc.subject.keywordAuthorrutin-
dc.subject.keywordAuthorAspergillus niger-
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  • College of Human Ecology
  • Department of Food and Nutrition
Research Area Biochemistry & Molecular Biology, Food Science & Technology, Microbiology, 미생물학, 분자생물학, 식품공학

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